ArticleJournal of hypertension2017
Optimal diagnostic thresholds for diagnosis of orthostatic hypotension with a 'sit-to-stand test'.
Article in Journal of hypertension, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 4 of them syntheses that pooled it.
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Who cites it
39 citing papers in PubMed, 4 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- Effects of intensive blood pressure treatment on orthostatic hypertension: individual level meta-analysis.BMJ (Clinical research ed.) · 2025Pooled it
- Management of Hypertension and Blood Pressure Dysregulation in Patients with Parkinson's Disease-a Systematic Review.Current hypertension reports · 2021Pooled it
- Prevalence of postural hypotension in primary, community and institutional care: a systematic review and meta-analysis.BMC family practice · 2021Pooled it
- Orthostatic hypotension and symptomatic subclinical orthostatic hypotension increase risk of cognitive impairment: an integrated evidence review and analysis of a large older adult hypertensive cohort.European heart journal · 2018Pooled it
- Elevating blood pressure in neurogenic orthostatic hypotension: Investigating the efficacy and tolerability of rebreathing therapy.Autonomic neuroscience : basic & clinical · 2026Trial
- Long-term antipsychotic use, orthostatic hypotension and falls in older adults with Alzheimer's disease.European geriatric medicine · 2024Trial
- Body Position and Orthostatic Hypotension in Hypertensive Adults: Results from the Syst-Eur Trial.Hypertension (Dallas, Tex. : 1979) · 2023Trial
- Blood Pressure Lowering With Nilvadipine in Patients With Mild-to-Moderate Alzheimer Disease Does Not Increase the Prevalence of Orthostatic Hypotension.Journal of the American Heart Association · 2019Trial
- Associations between orthostatic hypotension and related factors in hospitalised older adults: a cross-sectional study in Turkey.BMC geriatrics · 2026Article
- Orthostatic blood pressure changes among adults in Ekiti state, Nigeria: Impact of socio-demographic, anthropometric, and biophysical factors.Physiological reports · 2026Article
- Understanding measurement of postural hypotension: a nationwide survey of general practice in England.The British journal of general practice : the journal of the Royal College of General Practitioners · 2026Article
- The feasibility of a set of physical resilience measurements in older patients admitted to the acute medical unit.BMC geriatrics · 2025Article
- Beat-to-Beat Blood Pressure Monitoring and Orthostatic Hypotension-Related Falls in Two Cohorts of Older Adults.Geriatrics (Basel, Switzerland) · 2025Article
- Noradrenergic cardiac denervation is associated with gait velocity in Parkinson disease: a dual ligand PET study.European journal of nuclear medicine and molecular imaging · 2024Article
- Cardiovascular autonomic dysfunction in post-COVID-19 syndrome: a major health-care burden.Nature reviews. Cardiology · 2024Review
- Telemedicine-Based Risk Program to Prevent Falls Among Older Adults: Protocol for a Randomized Quality Improvement Trial.JMIR research protocols · 2024Article
- Orthostatic Hypotension in Adults With Hypertension: A Scientific Statement From the American Heart Association.Hypertension (Dallas, Tex. : 1979) · 2024Review
- Medial longitudinal fasciculus (MLF)-syndrome in a multimorbid patient with alcohol use disorder: a case report.AME case reports · 2024Article
- Capturing postural blood pressure dynamics with near-infrared spectroscopy-measured cerebral oxygenation.GeroScience · 2023Article
- Reply to: Comment on: Comparison of supine and seated orthostatic hypotension assessments and their association with falls and orthostatic symptoms.Journal of the American Geriatrics Society · 2023Article
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveThis study aimed to identify optimal blood pressure cut-offs to diagnose orthostatic hypotension during a sit-to-stand manoeuvre.
methodsThis was a cross-sectional study of patients and healthy controls from the Vanderbilt Autonomic Dysfunction Center. Blood pressure was measured while supine, seated and standing. Blood pressure changes were calculated from supine-to-standing and seated-to-standing. Orthostatic hypotension was diagnosed on the basis of a supine-to-standing SBP drop at least 20 mmHg or a DBP drop at least 10 mmHg. Receiver operator characteristic (ROC) curves identified optimal sit-to-stand cut-offs.
resultsAmongst the 831 individuals, more had systolic orthostatic hypotension [n = 354 (43%)] than diastolic orthostatic hypotension [n = 305 (37%)] during lying-to-standing. The ROC curves had good characteristics [SBP area under curve = 0.916 (95% confidence interval: 0.896-0.936), P < 0.001; DBP area under curve = 0.930 (95% confidence interval: 0.909-0.950), P < 0.001]. A sit-to stand SBP drop at least 15 mmHg had optimal test characteristics (sensitivity = 80.2%; specificity = 88.9%; positive predictive value = 84.2%; negative predictive value = 85.8%), as did a DBP drop at least 7 mmHg (sensitivity = 87.2%; specificity = 87.2%; positive predictive value = 80.1%; negative predictive value = 92.0%).
conclusionsA sit-to-stand manoeuvre with lower diagnostic cut-offs for orthostatic hypotension provides a simple screening test for orthostatic hypotension in situations wherein a supine-to-standing manoeuvre cannot be easily performed. Our analysis suggests that a SBP drop at least 15 mmHg or a DBP drop at least 7 mmHg best optimizes sensitivity and specificity of this sit-to-stand test.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.