ArticleHuman vaccines & immunotherapeutics2017
Severe pertussis infection in infants less than 6 months of age: Clinical manifestations and molecular characterization.
Article in Human vaccines & immunotherapeutics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Antimicrobial resistance inEpidemiology and infection · 2026Pooled it
- Parent-driven transmission, off-label SMZ-TMP, and severe pertussis prediction in infants under 2 months: a real-world observational cohort of 527 cases.Frontiers in pediatrics · 2026Article
- Review
- Macrolide Resistance inAntibiotics (Basel, Switzerland) · 2022Review
- Clinical characteristics of 967 children with pertussis: a single-center analysis over an 8-year period in Beijing, China.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2022Article
- Automatic Identification of MALDI-TOF MS Database Using ClassicalComputational and mathematical methods in medicine · 2022Article
- Pertussis in Italy: how to protect the "unprotectable"?Human vaccines & immunotherapeutics · 2021Observational
- Pertussis in early life: underdiagnosed, severe, and risky disease. A seven-year experience in a pediatric tertiary-care hospital.Human vaccines & immunotherapeutics · 2021Article
- A data driven clinical algorithm for differential diagnosis of pertussis and other respiratory infections in infants.PloS one · 2020Article
- Trends in Hospital Admissions for Pertussis Infection: A Nationwide Retrospective Observational Study in Italy, 2002-2016.International journal of environmental research and public health · 2019Observational
- Hexavalent vaccines: characteristics of available products and practical considerations from a panel of Italian experts.Journal of preventive medicine and hygiene · 2018Article
- Maternal immunisation: What have been the gains? Where are the gaps? What does the future hold?F1000Research · 2018Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We conducted a study to determine the main traits of pertussis among unimmunized infants less than 6 months of age. From August 2012 to March 2015, 141 nasopharyngeal aspirates (NPAs) were collected from infants with respiratory symptoms attending 2 major hospitals in Rome. Clinical data were recorded and analyzed. Lab-confirmation was performed by culture and realtime PCR. B. pertussis virulence-associated genes (ptxP, ptxA and prn), together with multilocus variable-number tandem repeat analysis (MLVA), were also investigated by the sequence-based analysis on the DNAs extracted from positive samples. Antibiotic susceptibility with Etest was defined on 18 viable B. pertussis isolates. Samples from 73 infants resulted positives for B. pertussis. The median age of the patients was 45 d (range 7-165); 21 infants were treated with macrolides before hospital admission. Cough was reported for a median of 10 d before admission and 18 d after hospital discharge among infected infants, 84% of whom showed paroxysmal cough. No resistance to macrolides was detected. Molecular analysis identified MT27 as the predominant MLVA profile, combined with ptxP3-ptxA1-prn2 associated virulence genes. Although our data may not be generalized to the whole country, they provide evidence of disease severity among infants not vaccinated against pertussis. Moreover, genetically related B. pertussis strains, comprising allelic variants of virulence associated genes, were identified.
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