ArticleChildhood obesity (Print)2017
Leptin and Leptin-to-Adiponectin Ratio Predict Adiposity Gain in Nonobese Children over a Six-Year Period.
Article in Childhood obesity (Print), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Sexual dimorphism of leptin and adiposity in children between 0 and 10 years: a systematic review and meta-analysis.Biology of sex differences · 2022Pooled it
- Effects of Aerobic Exercise on the Serum Leptin Level and Heart Rate Variability in the Obese Girl Children.Computational intelligence and neuroscience · 2022Trial
- Longitudinal protein profiling of blood during childhood into early adulthood.Nature communications · 2026Article
- Two Sides of a Coin: Molecular, metabolic, and Phenotypic Convergence in Pediatric Undernutrition and Obesity.Current obesity reports · 2026Review
- Metaflammation's Role in Systemic Dysfunction in Obesity: A Comprehensive Review.International journal of molecular sciences · 2025Review
- Growth in height and its association with overweight and obesity in Mexican children: an evaluation based on a nationally representative sample (ENSANUT 2018).Frontiers in public health · 2024Article
- The role of adipokines and ghrelin in interactions and clinical implications in childhood obesity.Journal of education and health promotion · 2024Article
- Obesogenic neighborhood environment is associated with body fat and low-grade inflammation in Brazilian children: could the mother's BMI be a mediating factor?Public health nutrition · 2023Article
- Circadian variation of serum leptin and adipose tissue changes in children.Pediatric obesity · 2023Article
- Leptin/adiponectin ratio as a prognostic factor for increased weight gain in girls with central precocious puberty.Frontiers in endocrinology · 2023Article
- The "Adipo-Cerebral" Dialogue in Childhood Obesity: Focus on Growth and Puberty. Physiopathological and Nutritional Aspects.Nutrients · 2021Review
- Regulatory effect of mitoQ on the mtROS-NLRP3 inflammasome pathway in leptin-pretreated BEAS-2 cells.Experimental and therapeutic medicine · 2021Article
- Update on the Crosstalk Between Adipose Tissue and Mineral Balance in General Population and Chronic Kidney Disease.Frontiers in pediatrics · 2021Review
- Article
- Obesity Risk Assessment Tool for Low-Income Spanish Speaking Immigrant Parents with Young Children: Validity with BMI and Biomarkers of Obesity.Nutrients · 2020Article
- The association of maternal obesity and race with serum adipokines in pregnancy and postpartum: Implications for gestational weight gain and infant birth weight.Brain, behavior, & immunity - health · 2020Article
- The associations between some biological markers, obesity, and cardiovascular risk in Slovenian children and adolescents.BMC pediatrics · 2020Article
- Article
- Adiponectin and Cardiovascular Risk. From Pathophysiology to Clinic: Focus on Children and Adolescents.International journal of molecular sciences · 2019Review
- Metabolic trajectories across early adolescence: differences by sex, weight, pubertal status and race/ethnicity.Annals of human biology · 2019Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious longitudinal studies have shown inconsistent results regarding the influence of adipokines on changes in weight and body fat. We aimed to determine the predictive value of serum leptin, adiponectin, and their ratio on subsequent changes in obesity measures in children.
methodsTwo hundred forty-six obese and 532 nonobese children aged 6-11 years were remeasured for BMI and waist circumference after 6.4 ± 0.2 years. Z-score of BMI was used to standardize for age and sex. Obesity was defined using the international BMI cutoffs. Waist-to-height ratio (WHtR) was calculated to define central obesity using a boundary value of 0.5. Fasting serum leptin and adiponectin levels were measured at baseline.
resultsNewly identified obese children had significantly higher levels of leptin and leptin-to-adiponectin ratio than nonobese children. There were lower adiponectin levels in boys with persistent obesity versus those with transient obesity. After adjusting for age, Tanner stage, and corresponding adiposity measures at baseline, leptin levels and leptin-to-adiponectin ratio were positively associated with BMI Z-score gain in girls and WHtR gain in boys. An inverse association between leptin and BMI Z-score gain was detected in boys. Stratified analyses revealed significant associations only in the nonobese and prepubertal group. There were no significant associations between adiponectin and changes in obesity measures.
conclusionsHigh leptin levels and leptin-to-adiponectin ratio are sex-specific predictors of obesity measures gain in nonobese and prepubertal children. Body composition measurement is necessary to assess fat mass growth and distribution during childhood and adolescence.
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Registered trials
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