Evidence map›Paper›PMID 28128940›Full record

ArticleJournal of the American Chemical Society2017

Sequence-Selective Binding of Oligopeptides in Water through Hydrophobic Coding.

Joseph K Awino, Roshan W Gunasekara, Yan Zhao

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 73 citations in OpenAlex.

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  15. Substrate Protection in Controlled Enzymatic Transformation of Peptides and Proteins.Chembiochem : a European journal of chemical biology · 2021
    Article
  16. Article
  17. Sequence-Selective Protection of Peptides from Proteolysis.Angewandte Chemie (International ed. in English) · 2021
    Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Joseph K AwinoDepartment of Chemistry, Iowa State University , Ames, Iowa 50011-3111, United States.ORCID 0000-0003-3710-3014
Roshan W GunasekaraDepartment of Chemistry, Iowa State University , Ames, Iowa 50011-3111, United States.
Yan ZhaoDepartment of Chemistry, Iowa State University , Ames, Iowa 50011-3111, United States.ORCID 0000-0003-1215-2565
Iowa State University · US

Funding

Biomimetic Receptors for Small Hydrophobic Drugs, Carbohydrates, and OligopeptidesR01GM113883 · NIGMS · IOWA STATE UNIVERSITY · PI ZHAO, YAN · 2015 to 2018
$1.1M
NIGMS NIH HHS R01 GM113883
6 · The paper itself

Abstract

A general method for sequence-specific binding of peptides remains elusive despite decades of research. By creating an array of "hydrophobically coded dimples" on the surface of surface-core doubly cross-linked micelles, we synthesized water-soluble nanoparticle receptors to recognize peptides by the location, number, and nature of their hydrophobic side chains. Minute differences in the side chains could be distinguished, and affinities up to 20 nM were obtained for biologically active oligopeptides in water.

Indexed as

Binding SitesHydrophobic and Hydrophilic InteractionsMolecular ConformationMolecular ImprintingNanoparticlesOligopeptidesParticle SizeSurface PropertiesWaterOligopeptidesWater

Identifiers

PMID28128940
PMCPMC5310974
OpenAlexW2580662856

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.