Evidence map›Paper›PMID 28128928›Full record

ArticleACS chemical neuroscience2017

A Direct in Vivo Comparison of the Melanocortin Monovalent Agonist Ac-His-DPhe-Arg-Trp-NH

Cody J Lensing, Danielle N Adank, Stacey L Wilber, Katie T Freeman, Sathya M Schnell, Robert C Speth, Adam T Zarth, Carrie Haskell-Luevano

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Peripheral MC1R Activation Modulates Immune Responses and is Neuroprotective in a Mouse Model of Parkinson's Disease.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2023
    Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Bench-top to clinical therapies: A review of melanocortin ligands from 1954 to 2016.Biochimica et biophysica acta. Molecular basis of disease · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cody J LensingDepartment of Medicinal Chemistry, University of Minnesota , Minneapolis, Minnesota 55455, United States.
Danielle N AdankDepartment of Medicinal Chemistry, University of Minnesota , Minneapolis, Minnesota 55455, United States.
Stacey L WilberDepartment of Medicinal Chemistry, University of Minnesota , Minneapolis, Minnesota 55455, United States.
Katie T FreemanDepartment of Medicinal Chemistry, University of Minnesota , Minneapolis, Minnesota 55455, United States.
Sathya M SchnellDepartment of Medicinal Chemistry, University of Minnesota , Minneapolis, Minnesota 55455, United States.
Robert C SpethCollege of Pharmacy, Nova Southeastern University , Fort Lauderdale, Florida 33328-2018, United States.
Adam T ZarthDepartment of Medicinal Chemistry, University of Minnesota , Minneapolis, Minnesota 55455, United States.
Carrie Haskell-LuevanoDepartment of Medicinal Chemistry, University of Minnesota , Minneapolis, Minnesota 55455, United States.ORCID 0000-0002-6783-5972

Funding

Melanocortin Selective LigandsR01DK091906 · NIDDK · UNIVERSITY OF MINNESOTA · PI HASKELL-LUEVANO, CARRIE · 2012 to 2015
$1.8M
Novel Melanocortin Receptor Probe DiscoveryR01DK108893 · NIDDK · UNIVERSITY OF MINNESOTA · PI HASKELL-LUEVANO, CARRIE · 2016 to 2019
$1.5M
NIDDK NIH HHS R01 DK091906NIDDK NIH HHS R01 DK108893
6 · The paper itself

Abstract

Bivalent ligands targeting putative melanocortin receptor dimers have been developed and characterized in vitro; however, studies of their functional in vivo effects have been limited. The current report compares the effects of homobivalent ligand CJL-1-87, Ac-His-DPhe-Arg-Trp-PEDG20-His-DPhe-Arg-Trp-NH

Indexed as

AnimalsEatingEnergy MetabolismHEK293 CellsHumansLigandsMiceOligopeptidesReceptors, MelanocortinLigandsOligopeptidesReceptors, MelanocortinBRETinterleukin-6magnetic resonance imaginingMC3R-MC4R heterodimerMelanocortin homodimermelanotropinmetabolic serum stabilitymetabolic syndromeobesity

Identifiers

PMID28128928
PMCPMC5679024

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.