ArticleCancer biomarkers : section A of Disease markers2017
MicroRNA-21 contributes to the discrimination of chemoresistance in metastatic gastric cancer.
Article in Cancer biomarkers : section A of Disease markers, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Circulating miR-19, miR-27a, and miR-200c as novel biomarkers for resistance to neoadjuvant chemotherapy in gastric cancer patients: a pilot study.Scientific reports · 2025Trial
- Mechanisms of chemoresistance in gastric cancer: interplay between microRNAs and the tumor microenvironment.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
- Analyzing the Blueprint: Exploring the Molecular Profile of Metastasis and Therapeutic Resistance.International journal of molecular sciences · 2025Review
- Huashi Jiedu Decoction Enhances 5-Fluorouracil Efficacy in Gastric Cancer via miRNA-21-3p/p53 Pathway.Drug design, development and therapy · 2025Article
- Molecular roles of microRNA-21 and exosomal miR-21 in gastrointestinal cancers: diagnostic, therapeutic, and drug resistance insights.Frontiers in molecular biosciences · 2025Review
- Tumor microenvironment responsive MnJournal of nanobiotechnology · 2022Article
- Targeting non-coding RNAs to overcome cancer therapy resistance.Signal transduction and targeted therapy · 2022Review
- Contribution of MicroRNAs in Chemoresistance to Cisplatin in the Top Five Deadliest Cancer: An Updated Review.Frontiers in pharmacology · 2022Review
- The Molecular Roles and Clinical Implications of Non-Coding RNAs in Gastric Cancer.Frontiers in cell and developmental biology · 2021Review
- Mechanisms of Action And Clinical Implications of MicroRNAs in the Drug Resistance of Gastric Cancer.Frontiers in oncology · 2021Review
- Ratios of miRNAs in Peritoneal Exosomes are Useful Biomarkers to Predict Tumor Response to Intraperitoneal Chemotherapy in Patients with Peritoneal Metastases from Gastric Cancer.Annals of surgical oncology · 2020Article
- Plasma microRNA profiles: identification of miR-1229-3p as a novel chemoresistant and prognostic biomarker in gastric cancer.Scientific reports · 2020Article
- Non-coding RNA in drug resistance of gastric cancer.World journal of gastrointestinal oncology · 2019Review
- Exposure to Concentrated Ambient Fine Particulate Matter Induces Vascular Endothelial Dysfunction via miR-21.International journal of biological sciences · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMultidrug resistance in gastric cancer greatly impedes the efficacy of chemotherapy.
objectiveTo explore the efficacy of microRNA-21 (mir-21) in distinguishing metastatic gastric cancer (MGC) with chemoresistance.
methodsFrom April 2012 to May 2015, 92 MGC patients were enrolled. Cisplatin and fluorouracil-based systemic chemotherapy was given, and patients' characteristics and follow-up data were collected. In addition, miR-21 expression was determined in tumor tissue and plasma.
resultsSixty-seven patients responded to chemotherapy, and chemotherapy resistance was observed in 25 patients. miR-21 expression in tumor tissue and plasma was significantly elevated in the chemotherapy-resistant group (CRG) compared to the chemotherapy-sensitive group (CSG) (p< 0.001). miR-21 expression in tissue was associated with tumor differentiation (p= 0.042), and plasma miR-21 was correlated with gender (p= 0.016), tumor differentiation (p= 0.003), and number of metastatic sites (p< 0.001). Receiver operating characteristic (ROC) analysis indicated that miR-21 in tissue yielded an area under the ROC curve (AUC) of 0.830 (95%CI: 0.737-0.900, sensitivity: 88.0%, specificity: 68.7%) in distinguishing CRG from CSG; and plasma miR-21 yielded an AUC of 0.759 (95%CI: 0.658-0.842, sensitivity: 52.0%, specificity: 88.1%) in distinguishing CRG form CSG. Log-rank test and Cox proportional hazard regression analysis indicated that patients with higher miR-21 expression in tissue and plasma experienced shorter overall survival (P< 0.001).
conclusionmiR-21 could serve as a potential biomarker to identify MGC with chemoresistance.
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