Evidence map›Paper›PMID 28128735›Full record

ArticleCancer biomarkers : section A of Disease markers2017

Expression analysis of matrix metalloproteinase-13 in human gastric cancer in the presence of Helicobacter Pylori infection.

Shoaleh Sheibani, Reihaneh Alsadat Mahmoudian, Mohammad Reza Abbaszadegan, Jamshidkhan Chamani, Bahram Memar, Mehran Gholamin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer biomarkers : section A of Disease markers, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Strategies ofFrontiers in cellular and infection microbiology · 2024
    Review
  4. Article
  5. Article
  6. Matrix Metalloproteinases inInternational journal of molecular sciences · 2022
    Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Shoaleh SheibaniDepartment of Biophysics, Faculty of Science, Islamic Azad University-Mashhad Branch, Mashhad, Iran.
Reihaneh Alsadat MahmoudianImmunology Research Center, BuAli Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohammad Reza AbbaszadeganImmunology Research Center, BuAli Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Jamshidkhan ChamaniDepartment of Biophysics, Faculty of Science, Islamic Azad University-Mashhad Branch, Mashhad, Iran.
Bahram MemarPathology Department, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Mehran GholaminDepartment of Laboratory Sciences, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran.
Mashhad University of Medical Sciences · IRIslamic Azad University, Mashhad · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMatrix metalloproteinases (MMPs) can degrade essentially the extracellular matrix (ECM) components. MMPs are important regulators of tumor growth; hence the enzymes are considered as important targets for cancer therapy. MMP-13 is specially activated in gastric cancer and promotes the invasiveness of the primary tumors. Helicobacter Pylori (H.pylori) interacts with gastric epithelial cells and stimulates it to produce MMP-13in vitro.

objectiveThe relation between MMP-13 gene expression and clinicopathological characteristics of gastric cancer in the presence of H.pylori infection was investigated in fifty patients.

methodsThe level of MMP-13 gene expression was measured by quantitative Real-time PCR method and was evaluated between two groups of normal and carcinomatous tissues.

resultsThe results showed 30% elevation of MMP-13 expression in tumor tissues. H.pylori infection did not have a significant effect on the expression of MMP-13. There was a correlation between gene expression and tumor type (P value = 0.032). In addition, there was a significant correlation between MMP-13 gene expression and tumor stage in intestinal group (P value = 0.023).

conclusionsBased on the results, it might be concluded that in intestinal group, immune system plays an important role in reducing gene expression. Results also showed over expression (60%) in diffuse group. These findings suggest that using MMP-13 inhibitors in diffuse group might contribute to the control of tumor growth.

Indexed as

AdultAgedAged, 80 and overBiomarkers, TumorCell ProliferationEpithelial CellsFemaleGene Expression Regulation, NeoplasticHelicobacter InfectionsHelicobacter pyloriHumansMaleMatrix Metalloproteinase 13Middle AgedStomach NeoplasmsBiomarkers, TumorMatrix Metalloproteinase 13MMP13 protein, humangastric cancerHelicobacter PyloriMMP-13real-time PCR

Identifiers

PMID28128735
PMCPMC13020622
OpenAlexW2581924610

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.