Evidence map›Paper›PMID 28128654›Full record

ArticleEuropean journal of preventive cardiology2017

Burden of carotid artery atherosclerosis in Chinese adults: Implications for future risk of cardiovascular diseases.

Robert Clarke, Huaidong Du, Om Kurmi, Sarah Parish, Meng Yang, Matthew Arnold, Yu Guo, Zheng Bian, Liang Wang, Yuexin Chen and 7 more

Open access · greenAbstract readComparative Study
In one paragraph

Article in European journal of preventive cardiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 3 countries.

Robert Clarke1 Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, UK.
Huaidong Du1 Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, UK.
Om Kurmi1 Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, UK.
Sarah Parish1 Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, UK.
Meng Yang3 Division of Ultrasound Diagnosis, Peking Union Medical College Hospital, Beijing, China.
Matthew Arnold1 Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, UK.
Yu Guo4 Chinese Academy of Medical Sciences, Beijing, China.
Zheng Bian4 Chinese Academy of Medical Sciences, Beijing, China.
Liang Wang3 Division of Ultrasound Diagnosis, Peking Union Medical College Hospital, Beijing, China.
Yuexin Chen5 Centre of Vascular Surgery, Peking Union Medical College Hospital, Beijing, China.
Rudy Meijer6 Department of Radiology, University Medical Centre Utrecht, The Netherlands.
Sam Sansome1 Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, UK.
John McDonnell1 Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, UK.
Rory Collins1 Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, UK.
Liming Li4 Chinese Academy of Medical Sciences, Beijing, China.
Zhengming Chen1 Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, UK.
China Kadoorie Biobank Collaborative Group
University of Oxford · GBChinese Academy of Medical Sciences & Peking Union Medical College · CNPeking Union Medical College Hospital · CNPeking University · CNUniversity Medical Center Utrecht · NL

Funding

British Heart Foundation CH/1996001/9454Cancer Research UK A16896Cancer Research UK A8760Cancer Research UK C500/A16896Medical Research Council A310Medical Research Council MC_PC_14135Medical Research Council MC_U137686851Medical Research Council MC_UU_12026/2Wellcome Trust 088158Wellcome Trust 104085Wellcome Trust 104085/Z/14/ZWellcome Trust 202922
6 · The paper itself

Abstract

Background Population-based studies of ultrasound measures of carotid atherosclerosis are informative about future risks of cardiovascular disease. Design Cross-sectional studies of carotid artery atherosclerosis in 24,822 Chinese adults from the China Kadoorie Biobank and 2579 Europeans from the UK Biobank. Methods Mean intima-media thickness of the common carotid arteries and presence of carotid artery plaque were examined in the China Kadoorie Biobank study. The carotid intima-media thickness (cIMT) findings in Chinese (mean age 59 years) were compared with a European population (mean age 62 years). Results Overall, the mean cIMT in Chinese was 0.70 mm (SD 0.16) and increased with age by 0.08 mm (SE 0.008) per 10-years older age. About 31% of the Chinese had carotid plaques and the prevalence varied 10-fold with age (6% at 40-49 to 63% at 70-89 years) and four-fold by region (range, 14%-57%). After adjustment for age, sex and region, plaque prevalence was higher in smokers than in non-smokers (36% vs. 28%) and two-fold higher in individuals with systolic blood pressure ≥160 mmHg than those with systolic blood pressure <120 mmHg (44% vs. 22%) in the China Kadoorie Biobank study. Mean cIMT was similar in the younger Chinese and European adults, but increased more steeply with age in the Chinese ( p = 0.002). Conclusions About one-third of Chinese adults had carotid plaques. The rate of progression of carotid atherosclerosis with age was more extreme in the Chinese compared with the European population, highlighting the need for more intensive strategies for cardiovascular disease prevention in China.

Indexed as

AdultAgedAged, 80 and overAge DistributionAsian PeopleCarotid Artery DiseasesCarotid Intima-Media ThicknessCerebrovascular DisordersChinaCross-Sectional StudiesDisease ProgressionFemaleHealth StatusHumansIncidenceMaleAtherosclerosiscarotid intima-media thicknessplaques

Identifiers

PMID28128654
PMCPMC6675599
OpenAlexW2580848512

What OpenQuestion holds

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LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.