Evidence map›Paper›PMID 28128026›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2017

Amide proton transfer-weighted MRI detection of traumatic brain injury in rats.

Hong Zhang, Wenzhu Wang, Shanshan Jiang, Yi Zhang, Hye-Young Heo, Xianlong Wang, Yun Peng, Jian Wang, Jinyuan Zhou

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 37 citations in OpenAlex.

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  16. Improving Amide Proton Transfer-Weighted MRI Reconstruction Using T2-Weighted Images.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Hong Zhang1 Division of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, MD, USA.
Wenzhu Wang3 Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA.
Shanshan Jiang1 Division of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, MD, USA.
Yi Zhang1 Division of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, MD, USA.
Hye-Young Heo1 Division of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, MD, USA.
Xianlong Wang1 Division of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, MD, USA.
Yun Peng2 Department of Radiology, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Jian Wang3 Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA.
Jinyuan Zhou1 Division of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, MD, USA.
Johns Hopkins University · USBeijing Children’s Hospital · CNJohns Hopkins Medicine · US

Funding

Amide Proton Transfer (APT) MRI of Brain Tumors at 3T and 7TR01EB009731 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI ZHOU, JINYUAN · 2009 to 2016
$2.9M
US-China Collaborative Research on Stroke ImagingR01NS083435 · NINDS · JOHNS HOPKINS UNIVERSITY · PI ZHOU, JINYUAN · 2013 to 2015
$588k
NIBIB NIH HHS R01 EB009731NINDS NIH HHS R01 NS083435
6 · The paper itself

Abstract

The purpose of this study was to explore the capability and uniqueness of amide proton transfer-weighted (APTw) imaging in the detection of primary and secondary injury after controlled cortical impact (CCI)-induced traumatic brain injury (TBI) in rats. Eleven adult rats had craniotomy plus CCI surgery under isoflurane anesthesia. Multi-parameter MRI data were acquired at 4.7 T, at eight time points (1, 6 h, and 1, 2, 3, 7, 14, and 28 days after TBI). At one and six hours post-injury, average APTw signal intensities decreased significantly in the impacted and peri-lesional areas due to tissue acidosis. A slightly high APTw signal was seen in the core lesion area with respect to the peri-lesional area, which was due to hemorrhage, as shown by T

Indexed as

AcidosisAmidesAnimalsBrain Injuries, TraumaticBrain IschemiaCerebral HemorrhageInflammationMagnetic Resonance ImagingNeuroimagingRatsTime FactorsAmidesAmide proton transfer-weighted imaginghemorrhageischemianeuroinflammationtraumatic brain injury

Identifiers

PMID28128026
PMCPMC5624391
OpenAlexW2583064483

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.