Evidence map›Paper›PMID 28127962›Full record

ReviewACS chemical neuroscience2017

Hitchhiker's Guide to Voltammetry: Acute and Chronic Electrodes for in Vivo Fast-Scan Cyclic Voltammetry.

Nathan T Rodeberg, Stefan G Sandberg, Justin A Johnson, Paul E M Phillips, R Mark Wightman

Open access · greenAbstract readReview
In one paragraph

Review in ACS chemical neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed, 1 pooled it
9.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

118 citing papers in PubMed, 1 synthesis or guideline pooled it, 233 citations in OpenAlex.

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  13. A Poly(methacrolein-Nanomaterials (Basel, Switzerland) · 2025
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58 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Nathan T RodebergDepartment of Chemistry and ‡Neuroscience Center, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599-3290, United States.
Stefan G SandbergDepartment of Chemistry and ‡Neuroscience Center, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599-3290, United States.
Justin A JohnsonDepartment of Chemistry and ‡Neuroscience Center, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599-3290, United States.
Paul E M PhillipsDepartment of Chemistry and ‡Neuroscience Center, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599-3290, United States.
R Mark WightmanDepartment of Chemistry and ‡Neuroscience Center, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599-3290, United States.ORCID 0000-0003-2198-139X
University of North Carolina at Chapel Hill · US

Funding

Therapeutic Potential of Kappa Antagonists in the Adjunctive Treatment of Psychotic DepressionP50MH106428 · NIMH · UNIVERSITY OF WASHINGTON · PI CHAVKIN, CHARLES · 2015 to 2019
$7.6M
DYNAMICS OF IN VIVO DOPAMINE RELEASER01DA010900 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WIGHTMAN, ROBERT MARK · 1997 to 2017
$5.1M
Electrochemical tools to measure local cerebral blood flow and metabolismR01DA032530 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WIGHTMAN, ROBERT MARK · 2012 to 2016
$1.8M
Diametric changes in phasic dopamine to contingent and non-contingent drug cues in the regulation of drug taking and drug seekingR01DA039687 · NIDA · UNIVERSITY OF WASHINGTON · PI PHILLIPS, PAUL E. M. · 2015 to 2019
$1.7M
NIDA NIH HHS R01 DA010900NIDA NIH HHS R01 DA032530NIDA NIH HHS R01 DA039687NIMH NIH HHS P50 MH106428
6 · The paper itself

Abstract

Fast-scan cyclic voltammetry (FSCV) has been used for over 20 years to study rapid neurotransmission in awake and behaving animals. These experiments were first carried out with carbon-fiber microelectrodes (CFMs) encased in borosilicate glass, which can be inserted into the brain through micromanipulators and guide cannulas. More recently, chronically implantable CFMs constructed with small diameter fused-silica have been introduced. These electrodes can be affixed in the brain with minimal tissue response, which permits longitudinal measurements of neurotransmission in single recording locations during behavior. Both electrode designs have been used to make novel discoveries in the fields of neurobiology, behavioral neuroscience, and psychopharmacology. The purpose of this Review is to address important considerations for the use of FSCV to study neurotransmitters in awake and behaving animals, with a focus on measurements of striatal dopamine. Common issues concerning experimental design, data collection, and calibration are addressed. When necessary, differences between the two methodologies (acute vs chronic recordings) are discussed. The topics raised in this Review are particularly important as the field moves beyond dopamine toward new neurochemicals and brain regions.

Indexed as

ElectrodesWakefulnessAnimalsBrainElectrochemical TechniquesHumanscarbon-fiber microelectrodeschemometricsdopamineFast-scan cyclic voltammetryprincipal component regression

Identifiers

PMID28127962
PMCPMC5783156
OpenAlexW2579983465

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.