Evidence map›Paper›PMID 28127922›Full record

ArticleWorld psychiatry : official journal of the World Psychiatric Association (WPA)2017

Excess mortality in persons with severe mental disorders: a multilevel intervention framework and priorities for clinical practice, policy and research agendas.

Nancy H Liu, Gail L Daumit, Tarun Dua, Ralph Aquila, Fiona Charlson, Pim Cuijpers, Benjamin Druss, Kenn Dudek, Melvyn Freeman, Chiyo Fujii and 19 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World psychiatry : official journal of the World Psychiatric Association (WPA), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04671225 (Psychoeducation for Patients With Bipolar Disorder in Rwanda), which is not on this map. Cited by 342 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
342citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04671225 nacompletednot on this mapstarted 2021, after this paper: background citation

Psychoeducation for Patients With Bipolar Disorder in Rwanda

TypeinterventionalSponsorUniversity of AarhusRan2021 to 2022Enrolled154ConditionsBipolar DisorderArmsGroups Psychoeducation, Waiting-list
3 · Its place in the literature

Who cites it

342 citing papers in PubMed, 10 syntheses or guidelines pooled it.

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  4. End-of-life care for people with severe and persistent mental illness and a life-limiting disease: An umbrella review.European psychiatry : the journal of the Association of European Psychiatrists · 2025
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282 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Nancy H LiuWorld Health Organization, Geneva, Switzerland.
Gail L DaumitJohns Hopkins Medical Institutions, Baltimore, MD, USA.
Tarun DuaWorld Health Organization, Geneva, Switzerland.
Ralph AquilaFountain House, New York, NY, USA.
Fiona CharlsonQueensland Centre for Mental Health Research, Wacol, QLD, Australia.
Pim CuijpersVrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Benjamin DrussEmory University, Atlanta, GA, USA.
Kenn DudekFountain House, New York, NY, USA.
Melvyn FreemanNational Department of Health, Johannesburg, South Africa.
Chiyo FujiiNational Institute of Mental Health, Tokyo, Japan.
Wolfgang GaebelHeinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Ulrich HegerlUniversitätsklinikum Leipzig, Leipzig, Germany.
Itzhak LevavUniversity of Haifa, Haifa, Israel.
Thomas Munk LaursenAarhus University, Aarhus, Denmark.
Hong MaInstitute of Mental Health, Beijing, P.R. China.
Mario MajDepartment of Psychiatry, University of Naples SUN, Naples, Italy.
Maria Elena Medina-MoraNational Institute of Psychiatry Ramón de la Fuente Muñiz, Mexico City, Mexico.
Merete NordentoftUniversity of Copenhagen, Copenhagen, Denmark.
Dorairaj PrabhakaranPublic Health Foundation of India, Haryana, India.
Karen PrattFountain House, New York, NY, USA.
Martin PrinceInstitute of Psychiatry, King's College London, London, UK.
Thara RangaswamySchizophrenia Research Foundation, Chennai, India.
David ShiersHealthy Active Lives, Longsdon, Stoke-on-Trent, UK.
Ezra SusserColumbia University, New York, NY, USA.
Graham ThornicroftInstitute of Psychiatry, King's College London, London, UK.
Kristian WahlbeckFinnish Association for Mental Health, Helsinki, Finland.
Abe Fekadu WassieAddis Ababa University, Addis Ababa, Ethiopia.
Harvey WhitefordQueensland Centre for Mental Health Research, Wacol, QLD, Australia.
Shekhar SaxenaWorld Health Organization, Geneva, Switzerland.

Funding

Developing and Translating Interventions to Decrease Mortality Disparities in SMIK24MH093763 · NIMH · JOHNS HOPKINS UNIVERSITY · PI DAUMIT, GAIL L. · 2012 to 2016
$830k
NIMH NIH HHS K24 MH093763World Health Organization 001
6 · The paper itself

Abstract

Excess mortality in persons with severe mental disorders (SMD) is a major public health challenge that warrants action. The number and scope of truly tested interventions in this area remain limited, and strategies for implementation and scaling up of programmes with a strong evidence base are scarce. Furthermore, the majority of available interventions focus on a single or an otherwise limited number of risk factors. Here we present a multilevel model highlighting risk factors for excess mortality in persons with SMD at the individual, health system and socio-environmental levels. Informed by that model, we describe a comprehensive framework that may be useful for designing, implementing and evaluating interventions and programmes to reduce excess mortality in persons with SMD. This framework includes individual-focused, health system-focused, and community level and policy-focused interventions. Incorporating lessons learned from the multilevel model of risk and the comprehensive intervention framework, we identify priorities for clinical practice, policy and research agendas.

Indexed as

bipolar disordercommunity level and policy-focused interventionsdepressionExcess mortalityhealth system-focused interventionsindividual-focused interventionsphysical healthrisk factorsschizophreniasevere mental disorders

Identifiers

PMID28127922
PMCPMC5269481

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.