Evidence map›Paper›PMID 28127623›Full record

ArticlePsychopharmacology2017

Regulation of cannabinoid CB

Glòria Salort, María Álvaro-Bartolomé, Jesús A García-Sevilla

Abstract read
PubMed Publisher
In one paragraph

Article in Psychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Future Aspects for Cannabinoids in Breast Cancer Therapy.International journal of molecular sciences · 2019
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Glòria SalortLaboratori de Neurofarmacologia, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS/IdisPa), Universitat de les Illes Balears, Cra. Valldemossa km 7.5, E-07122, Palma de Mallorca, Spain.
María Álvaro-BartoloméLaboratori de Neurofarmacologia, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS/IdisPa), Universitat de les Illes Balears, Cra. Valldemossa km 7.5, E-07122, Palma de Mallorca, Spain.
Jesús A García-SevillaLaboratori de Neurofarmacologia, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS/IdisPa), Universitat de les Illes Balears, Cra. Valldemossa km 7.5, E-07122, Palma de Mallorca, Spain. jesus.garcia-sevilla@uib.es.
Instituto de Salud Carlos III · ESResearch Institute of Health Sciences · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleCB

objectivesThe acute (JWH13) and the acute/chronic effects (AM630, JTE907, raloxifene) of CB

methodsMice were treated with CB

resultsJWH133 reduced cortical JNK (-27-45%) whereas AM630 acutely increased JNK in cortex (+61-148%), cerebellum (+34-40%), and striatum (+33-42%). JTE907 and raloxifene also increased cortical JNK (+31%-57%). Acute AM630, but not JWH133, increased cortical FADD, Bax, cytochrome c, and PARP cleavage. Repeated treatments with the three CB

conclusionsAM630 and JTE907 are CB

Indexed as

AnimalsApoptosisBrainCannabinoid Receptor AgonistsCannabinoidsDioxolesDown-RegulationDrug Inverse AgonismIndolesLigandsMaleMAP Kinase Kinase 4MiceQuinolonesRaloxifene HydrochlorideReceptor, Cannabinoid, CB21,1-dimethylbutyl-1-deoxy-Delta(9)-THCCannabinoid Receptor AgonistsCannabinoidsDioxolesIndolesiodopravadolineJTE 907LigandsMAP Kinase Kinase 4QuinolonesRaloxifene HydrochlorideReceptor, Cannabinoid, CB2AM630Cannabinoid CB2 receptorsConstitutive activityInverse agonistsJTE907Raloxifene

Identifiers

PMID28127623
OpenAlexW2582843216

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.