Evidence map›Paper›PMID 28127591›Full record

ArticleMethods report (RTI Press)2016

Tasty THC: Promises and Challenges of Cannabis Edibles.

Daniel G Barrus, Kristen L Capogrossi, Sheryl C Cates, Camille K Gourdet, Nicholas C Peiper, Scott P Novak, Timothy W Lefever, Jenny L Wiley

Abstract read
In one paragraph

Article in Methods report (RTI Press), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Gimmie the Gummies: Initial validation of the Edibles Marijuana Purchase Task.Experimental and clinical psychopharmacology · 2026
    Article
  3. Article
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  10. Recommendations for the Clinical Management and Prevention of Pediatric Cannabis Edible Ingestions.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2025
    Article
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  19. Review
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36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Daniel G BarrusRTI International, Research Triangle Park, NC 27709.
Kristen L CapogrossiRTI International, Research Triangle Park, NC 27709.
Sheryl C CatesRTI International, Research Triangle Park, NC 27709.
Camille K GourdetRTI International, Research Triangle Park, NC 27709.
Nicholas C PeiperRTI International, Research Triangle Park, NC 27709.
Scott P NovakRTI International, Research Triangle Park, NC 27709.
Timothy W LefeverRTI International, Research Triangle Park, NC 27709.
Jenny L WileyRTI International, Research Triangle Park, NC 27709.

Funding

THC RECEPTORSR01DA003672 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI WILEY, JENNY L. · 1985 to 2018
$4.9M
THC RECEPTORSR37DA003672 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI MARTIN, BILLY R · 1997 to 2006
$2.8M
NIDA NIH HHS R01 DA003672NIDA NIH HHS R37 DA003672
6 · The paper itself

Abstract

Food products containing cannabis extract (edibles) have emerged as a popular and lucrative facet of the legalized market for both recreational and medicinal cannabis. The many formulations of cannabis extracts used in edibles present a unique regulatory challenge for policy makers. Though edibles are often considered a safe, discreet, and effective means of attaining the therapeutic and/or intoxicating effects of cannabis without exposure to the potentially harmful risks of cannabis smoking, little research has evaluated how ingestion differs from other methods of cannabis administration in terms of therapeutic efficacy, subjective effects, and safety. The most prominent difference between ingestion and inhalation of cannabis extracts is the delayed onset of drug effect with ingestion. Consumers often do not understand this aspect of edible use and may consume a greater than intended amount of drug before the drug has taken effect, often resulting in profoundly adverse effects. Written for the educated layperson and for policy makers, this paper explores the current state of research regarding edibles, highlighting the promises and challenges that edibles present to both users and policy makers, and describes the approaches that four states in which recreational cannabis use is legal have taken regarding regulating edibles.

Identifiers

PMID28127591
PMCPMC5260817

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.