Evidence map›Paper›PMID 28127555›Full record

ArticleBioMed research international2017

Preparation and Characterization of Hyaluronic Acid-Polycaprolactone Copolymer Micelles for the Drug Delivery of Radioactive Iodine-131 Labeled Lipiodol.

Shih-Cheng Chen, Ming-Hui Yang, Tze-Wen Chung, Ting-Syuan Jhuang, Jean-Dean Yang, Ko-Chin Chen, Wan-Jou Chen, Ying-Fong Huang, Shiang-Bin Jong, Wan-Chi Tsai and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Hydrogels: Properties and Applications in Biomedicine.Molecules (Basel, Switzerland) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shih-Cheng ChenOffice of Research and Development, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Ming-Hui YangCenter for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Tze-Wen ChungDepartment of Biomedical Engineering, National Yang-Ming University, Taipei 112, Taiwan.
Ting-Syuan JhuangInvasive Cardiac Laboratory, Tan Tock Seng Hospital, Singapore 308433.
Jean-Dean YangDepartment of Chemistry, Chung Yuan Christian University, Taoyuan 320, Taiwan.
Ko-Chin ChenDepartment of Pathology, Changhua Christian Hospital, Changhua 500, Taiwan.
Wan-Jou ChenDepartment of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Ying-Fong HuangDepartment of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Department of Nuclear Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
Shiang-Bin JongDepartment of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Department of Nuclear Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
Wan-Chi TsaiDepartment of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
Po-Chiao LinDepartment of Chemistry, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
Yu-Chang TyanOffice of Research and Development, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung 804, Taiwan; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.ORCID 0000-0002-1917-5893

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Micelles, with the structure of amphiphilic molecules including a hydrophilic head and a hydrophobic tail, are recently developed as nanocarriers for the delivery of drugs with poor solubility. In addition, micelles have shown many advantages, such as enhanced permeation and retention (EPR) effects, prolonged circulation times, and increased endocytosis through surface modification. In this study, we measured the critical micelle concentrations, diameters, stability, and cytotoxicity and the cell uptake of micelles against hepatic cells with two kinds of hydrophilic materials: PEG-PCL and HA-g-PCL. We used

Indexed as

Drug Delivery SystemsCell LineCell SurvivalContrast MediaDrug CarriersDrug StabilityEthiodized OilHepatocytesHep G2 CellsHumansHyaluronic AcidHydrophobic and Hydrophilic InteractionsIodine RadioisotopesMicellesParticle SizePolyestersContrast MediaDrug CarriersEthiodized OilHyaluronic Acidhyaluronic acid-polyethyleneglycol-polycaprolactone copolymerIodine RadioisotopesMicellespolycaprolactonePolyestersRadiopharmaceuticals

Identifiers

PMID28127555
PMCPMC5239969

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.