Evidence map›Paper›PMID 28127511›Full record

ArticleBrain and behavior2017

High-angular resolution diffusion imaging tractography of cerebellar pathways from newborns to young adults.

Thomas J Re, Jacob Levman, Ashley R Lim, Andrea Righini, Patricia Ellen Grant, Emi Takahashi

Open access · goldAbstract read
In one paragraph

Article in Brain and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Involvement of the Cerebellar Peduncles inInternational journal of molecular sciences · 2025
    Review
  5. Article
  6. A detailed spatiotemporal atlas of the white matter tracts for the fetal brain.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Quantitative analyses of high-angular resolution diffusion imaging (HARDI)-derived long association fibers in children with sensorineural hearing loss.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2020
    Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Thomas J ReDepartment of Radiology Boston Children's Hospital Harvard Medical School Boston MA USA; Fetal-Neonatal Brain Imaging and Developmental Science Center Boston Children's Hospital Harvard Medical School Boston MA USA; Department of Radiology University of Milan Milan Italy.
Jacob LevmanFetal-Neonatal Brain Imaging and Developmental Science Center Boston Children's Hospital Harvard Medical School Boston MA USA; Division of Newborn Medicine Department of Medicine Boston Children's Hospital Harvard Medical School Boston MA USA.
Ashley R LimDivision of Newborn Medicine Department of Medicine Boston Children's Hospital Harvard Medical School Boston MA USA; Department of Behavioral Neuroscience Northeastern University Boston MA USA.
Andrea RighiniDepartment of Pediatric Radiology and Neuroradiology Children's Hospital V. Buzzi Milan Italy.
Patricia Ellen GrantDepartment of Radiology Boston Children's Hospital Harvard Medical School Boston MA USA; Fetal-Neonatal Brain Imaging and Developmental Science Center Boston Children's Hospital Harvard Medical School Boston MA USA; Division of Newborn Medicine Department of Medicine Boston Children's Hospital Harvard Medical School Boston MA USA.
Emi TakahashiFetal-Neonatal Brain Imaging and Developmental Science Center Boston Children's Hospital Harvard Medical School Boston MA USA; Division of Newborn Medicine Department of Medicine Boston Children's Hospital Harvard Medical School Boston MA USA.
Boston Children's Hospital · USHarvard University · USCenter for Pain and the Brain · USOspedale dei Bambini Vittore Buzzi · IT

Funding

Mouse Neurodevelopmental Behavior CoreU54HD090255 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI POMEROY, SCOTT LOREN · 2016 to 2020
$5.2M
Development of Brain Connectivity in Human Fetus, Newborn, and Toddler AgesR01HD078561 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI TAKAHASHI (OKI), EMI · 2014 to 2018
$1.7M
Development of Brain Connectivity in the Human FetusR21HD069001 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI TAKAHASHI (OKI), EMI · 2012 to 2013
$467k
Aberrant Patterns of Human Brain Connectivity and Gyral StructuresR03NS091587 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI TAKAHASHI (OKI), EMI · 2015 to 2016
$177k
NICHD NIH HHS R01 HD078561NICHD NIH HHS R21 HD069001NICHD NIH HHS U54 HD090255NINDS NIH HHS R03 NS091587
6 · The paper itself

Abstract

introductionMany neurologic and psychiatric disorders are thought to be due to, or result in, developmental errors in neuronal cerebellar connectivity. In this connectivity analysis, we studied the developmental time-course of cerebellar peduncle pathways in pediatric and young adult subjects.

methodsA cohort of 80 subjects, newborns to young adults, was studied on a 3T MR system with 30 diffusion-weighted measurements with high-angular resolution diffusion imaging (HARDI) tractography.

resultsQualitative and quantitative results were analyzed for age-based variation. In subjects of all ages, the superior cerebellar peduncle pathway (SCP) and two distinct subpathways of the middle cerebellar peduncle (MCP), as described in previous DISCUSSION: Our findings showed that the inferior cerebellar peduncle pathway (ICP), involved primarily in proprioception and balance appears to have a later onset followed by more rapid development than that exhibited in other tracts. We hope that this study may provide an initial point of reference for future studies of normal and pathologic development of cerebellar connectivity.

Indexed as

AdolescentAdultCerebellumChildChild, PreschoolDiffusion Tensor ImagingFemaleHumansInfantInfant, NewbornMaleNeural PathwaysRetrospective StudiesYoung AdultcerebellumMRIpediatrictractography

Identifiers

PMID28127511
PMCPMC5256176
OpenAlexW2545695527

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.