Evidence map›Paper›PMID 28127430›Full record

ArticleBiomarker research2017

NOS1-, NOS3-, PIK3CA-, and MAPK-pathways in skin following radiation therapy.

Steffen Koerdt, Nadine Tanner, Niklas Rommel, Nils H Rohleder, Gesche Frohwitter, Oliver Ristow, Klaus-Dietrich Wolff, Marco R Kesting

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomarker research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Steffen Koerdt *Department of Oral and Maxillofacial Surgery, Technical University of Munich (TUM), Ismaninger Str. 22, D-81675 Munich, Germany.
Nadine Tanner *Department of Oral and Maxillofacial Surgery, Technical University of Munich (TUM), Ismaninger Str. 22, D-81675 Munich, Germany.
Niklas RommelDepartment of Oral and Maxillofacial Surgery, Technical University of Munich (TUM), Ismaninger Str. 22, D-81675 Munich, Germany.
Nils H RohlederDepartment of Oral and Maxillofacial Surgery, Technical University of Munich (TUM), Ismaninger Str. 22, D-81675 Munich, Germany.
Gesche FrohwitterDepartment of Oral and Maxillofacial Surgery, Technical University of Munich (TUM), Ismaninger Str. 22, D-81675 Munich, Germany.
Oliver RistowDepartment of Oral and Maxillofacial Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany.
Klaus-Dietrich WolffDepartment of Oral and Maxillofacial Surgery, Technical University of Munich (TUM), Ismaninger Str. 22, D-81675 Munich, Germany.
Marco R KestingDepartment of Oral and Maxillofacial Surgery, Technical University of Munich (TUM), Ismaninger Str. 22, D-81675 Munich, Germany.
Technical University of Munich · DEKlinikum rechts der Isar · DEUniversity Hospital Heidelberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEssential molecular pathways such as the MAPK pathway, NO system, or the influence of PIK3CA as an oncogene are known to regulate fundamental signalling networks. However, few knowledge about their role in the occurrence of wound healing disorders (WHD) following radiation therapy (RT) exists. This study aims to evaluate the expression profiles of specific molecular pathway marker genes.

methodsExpression profiles of the genes encoding MAPK, NOS1, NOS3, and PIK3CA were analyzed, by RT-PCR, in specimens from patients with and without a history of RT to the head and neck. Clinical data on the occurrence of cervical WHDs were analyzed.

resultsExpression analysis of patients with postoperative WHDs revealed a significant increase in MAPK expression compared to the control group without occurrence of postoperative WHDs. PIK3CA showed a significantly increased expression in patients with a history of RT. Expression analysis of all other investigated genes did not reveal significant differences.

conclusionsThis current study is able to show the influence of RT on different molecular pathways. This underlines the crucial role of specific molecular networks, responsible for the occurrence of long-term radiation toxicity such as WHDs. Additional studies should be carried out to identify possible starting points for therapeutic interventions.

Indexed as

MAPKNOSPCRPIK3CARadiation therapy

Identifiers

PMID28127430
PMCPMC5251289
OpenAlexW2578690048

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.