ArticleJournal of therapeutic ultrasound2017
An evaluation of the sonoporation potential of low-boiling point phase-change ultrasound contrast agents in vitro.
Article in Journal of therapeutic ultrasound, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Evaluation of cavitation enhancements in low-boiling point (< -2°C) perfluorocarbon nanodroplet and microbubble mixtures using therapeutic ultrasound pulses.Ultrasonics sonochemistry · 2026Article
- Molecular Ultrasound Imaging.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026Review
- Ultrasound-Mediated Antibiotic Delivery to In Vivo Biofilm Infections: A Review.Chembiochem : a European journal of chemical biology · 2024Review
- Article
- The Evolution and Recent Trends in Acoustic Targeting of Encapsulated Drugs to Solid Tumors: Strategies beyond Sonoporation.Pharmaceutics · 2023Review
- Overcoming biological barriers to improve treatment of a Staphylococcus aureus wound infection.Cell chemical biology · 2023Article
- An Analysis of Sonothrombolysis and Cavitation for Retracted and Unretracted Clots Using Microbubbles Versus Low-Boiling-Point Nanodroplets.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2022Article
- Spatiotemporal control of myofibroblast activation in acoustically-responsive scaffolds via ultrasound-induced matrix stiffening.Acta biomaterialia · 2022Article
- Harnessing ultrasound-stimulated phase change contrast agents to improve antibiotic efficacy against methicillin-resistantBiofilm · 2021Article
- Improving Release of Liposome-Encapsulated Drugs with Focused Ultrasound and Vaporizable Droplet-Liposome Nanoclusters.Pharmaceutics · 2021Article
- A Highly Efficient One-for-All Nanodroplet for Ultrasound Imaging-Guided and Cavitation-Enhanced Photothermal Therapy.International journal of nanomedicine · 2021Article
- Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications.Beilstein journal of nanotechnology · 2021Review
- A Comparison of Sonothrombolysis in Aged Clots between Low-Boiling-Point Phase-Change Nanodroplets and Microbubbles of the Same Composition.Ultrasound in medicine & biology · 2020Article
- Ultrasound-Stimulated Phase-Change Contrast Agents for Transepithelial Delivery of Macromolecules, Toward Gastrointestinal Drug Delivery.Ultrasound in medicine & biology · 2019Article
- Multicore Liquid Perfluorocarbon-Loaded Multimodal Nanoparticles for Stable Ultrasound andAdvanced functional materials · 2019Article
- Control of Acoustic Cavitation for Efficient Sonoporation with Phase-Shift Nanoemulsions.Ultrasound in medicine & biology · 2019Article
- Ultrasound-responsive droplets for therapy: A review.Journal of controlled release : official journal of the Controlled Release Society · 2019Review
- Review on Acoustic Droplet Vaporization in Ultrasound Diagnostics and Therapeutics.BioMed research international · 2019Review
- Gas Embolization in a Rodent Model of Hepatocellular Carcinoma Using Acoustic Droplet Vaporization.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2018Article
- Spatial-Temporal Cellular Bioeffects from Acoustic Droplet Vaporization.Theranostics · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundPhase-change ultrasound contrast agents (PCCAs) offer a solution to the inherent limitations associated with using microbubbles for sonoporation; they are characterized by prolonged circulation lifetimes, and their nanometer-scale sizes may allow for passive accumulation in solid tumors. As a first step towards the goal of extravascular cell permeabilization, we aim to characterize the sonoporation potential of a low-boiling point formulation of PCCAs in vitro.
methodsParameters to induce acoustic droplet vaporization and subsequent microbubble cavitation were optimized in vitro using high-speed optical microscopy. Sonoporation of pancreatic cancer cells in suspension was then characterized at a range of pressures (125-600 kPa) and pulse lengths (5-50 cycles) using propidium iodide as an indicator molecule.
resultsWe achieved sonoporation efficiencies ranging from 8 ± 1% to 36 ± 4% (percent of viable cells), as evidenced by flow cytometry. Increasing sonoporation efficiency trended with increasing pulse length and peak negative pressure.
conclusionsWe conclude that PCCAs can be used to induce the sonoporation of cells in vitro, and our results warrant further investigation into the use of PCCAs as extravascular sonoporation agents in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.