Expression of Pro-inflammatory Genes in Lesions and Neutrophils during

Soheyla Akhzari, Hossein Rezvan, Masoud Zolhavarieh

Open access · greenAbstract read

In one paragraph

Article in Iranian journal of parasitology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.3field-weighted citation impact, top 26% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

Designing of RNA Molecule Translating for Activitable Melittin as Selective Targeting ofIranian journal of parasitology
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Soheyla AkhzariDept. of Laboratory Sciences, School of Veterinary Sciences, Bu-Ali Sina University, Hamadan, Iran.

Hossein RezvanDept. of Laboratory Sciences, School of Veterinary Sciences, Bu-Ali Sina University, Hamadan, Iran.

Masoud ZolhavariehDept. of Laboratory Sciences, School of Veterinary Sciences, Bu-Ali Sina University, Hamadan, Iran; Dept. of Clinical Sciences, Faculty of Para-Veterinary Sciences, Bu-Ali Sina University, Hamedan, Iran.

Bu-Ali Sina University · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLeishmaniasis is a worldwide disease prevalent in tropical and sub-tropical countries in the world. Characterization of inflammatory responses produced in cutaneous leishmaniasis has not yet been completed.

methodsThe specific primers were designed for ten pro-inflammatory genes including CCL4, CCL3, TNF-α, IL-1α, IL-12P35, IL-12P40, CCL5, CCR5, IL-1β and IFN- γ and their expression were assessed and compared using RT-PCR in the lesion and peripheral blood neutrophils in

resultsNone of the pro-inflammatory genes was expressed in the healthy tissue and except IFN-γ others were down-regulated by the parasite in the lesion in untreated mice. In mice treated with anti-Leishmanial drugs, the expression of the pro-inflammatory genes restarted. The figure of pro-inflammatory gene expression in neutrophils was different was from the lesions in treated and untreated mice.

conclusion

Indexed as

BALB/c miceLeishmaniaLesionNeutrophilsPro-inflammatory genes

Identifiers

PMID28127365

PMCPMC5251182

OpenAlexW2566683755

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.