ArticleJournal of dentistry (Tehran, Iran)2016
Assessment of Surface Markers Derived from Human Periodontal Ligament Stem Cells: An In Vitro Study.
Article in Journal of dentistry (Tehran, Iran), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Biodentine Stimulates Calcium-Dependent Osteogenic Differentiation of Mesenchymal Stromal Cells from Periapical Lesions.International journal of molecular sciences · 2025Article
- Review
- Article
- Recent Advances on Electrospun Nanofibers for Periodontal Regeneration.Nanomaterials (Basel, Switzerland) · 2023Review
- A Narrative Review: Gingival Stem Cells as a Limitless Reservoir for Regenerative Medicine.International journal of molecular sciences · 2022Review
- Evaluation of periodontal ligament stem cell viability and proliferation on native collagen membranes: AnJournal of Indian Society of PeriodontologyArticle
- Isolation and immunohistochemical characterization of periodontal ligament stem cells: A preliminary study.Journal of Indian Society of PeriodontologyArticle
- Differential Efficacy of 2 Vibrating Orthodontic Devices to Alter the Cellular Response in Osteoblasts, Fibroblasts, and Osteoclasts.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesPeriodontal tissue regeneration for treatment of periodontal disease has not yet been mastered in tissue engineering. Stem cells, scaffold, and growth factors are the three main basic components of tissue engineering. Periodontal ligament (PDL) contains stem cells; however, the number, potency and features of these cells have not yet been understood. This study aimed to isolate and characterize the properties of PDL stem cells. MATERIALS AND
methodsIn this experimental study, samples were isolated from the PDL of extracted teeth of five patients and then stained immunohistochemically for detection of cell surface markers. Cells were then examined by immuno-flow cytometry for mesenchymal markers as well as for osteogenic and adipogenic differentiation.
resultsThe isolated cell population had fibroblast-like morphology and flow cytometry revealed that the mesenchymal surface markers were (means): CD90 (84.55), CD31 (39.97), CD166 (33.77), CD105 (31.19), CD45 (32/44), CD44 (462.11), CD34 (227.33), CD38 (86.94), CD13 (34.52) and CD73 (50.39). The PDL stem cells also differentiated into osteoblasts and adipocytes in osteogenic and adipogenic media, respectively.
conclusionsPDL stem cells expressed mesenchymal stem cell (MSC) markers and differentiated into osteoblasts and adipocytes in osteogenic and adipogenic media, respectively.
Indexed as
Identifiers
28127326PMC5250630What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.