ArticleFrontiers in immunology2016
Calorie Restriction Attenuates Terminal Differentiation of Immune Cells.
Article in Frontiers in immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Exploring the potential of bacterial-derived EVs for targeted enzyme replacement therapy: mechanisms, applications, and future directions.Archives of microbiology · 2025Review
- Intermittent fasting alleviates IMQ-induced psoriasis-like dermatitis via reduced γδT17 and monocytes in mice.Archives of dermatological research · 2024Article
- Dietary restriction mitigates the age-associated decline in mouse B cell receptor repertoire diversity.Cell reports · 2023Article
- The Important Roles of Natural Killer Cells in Liver Fibrosis.Biomedicines · 2023Review
- Cellular Senescence in Immunity against Infections.International journal of molecular sciences · 2022Review
- Effects of caloric restriction on the gut microbiome are linked with immune senescence.Microbiome · 2022Article
- Reduced frequency of cytotoxic CD56Cancer immunology, immunotherapy : CII · 2022Article
- Transcription factor Zhx2 restricts NK cell maturation and suppresses their antitumor immunity.The Journal of experimental medicine · 2021Article
- Strategies to Prevent or Remediate Cancer and Treatment-Related Aging.Journal of the National Cancer Institute · 2021Article
- Caloric Restriction May Help Delay the Onset of Frailty and Support Frailty Management.Frontiers in nutrition · 2021Review
- The effect of caloric restriction on the increase in senescence-associated T cells and metabolic disorders in aged mice.PloS one · 2021Article
- Interaction of Adipocyte Metabolic and Immune Functions Through TBK1.Frontiers in immunology · 2020Review
- Diet modulates the relationship between immune gene expression and functional immune responses.Insect biochemistry and molecular biology · 2019Article
- Transcriptome Analysis of the Thymus in Short-Term Calorie-Restricted Mice Using RNA-seq.International journal of genomics · 2018Article
- The effect of calorie restriction on mouse skeletal muscle is sex, strain and time-dependent.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Immune senescence is a natural consequence of aging and may contribute to frailty and loss of homeostasis in later life. Calorie restriction increases healthy life-span in C57BL/6J (but not DBA/2J) mice, but whether this is related to preservation of immune function, and how it interacts with aging, is unclear. We compared phenotypic and functional characteristics of natural killer (NK) cells and T cells, across the lifespan, of calorie-restricted (CR) and control C57BL/6 and DBA/2 mice. Calorie restriction preserves a naïve T cell phenotype and an immature NK cell phenotype as mice age. The splenic T cell populations of CR mice had higher proportions of CD11a
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.