Evidence map›Paper›PMID 28127284›Full record

ArticleFrontiers in human neuroscience2016

Cerebellar tDCS: A Novel Approach to Augment Language Treatment Post-stroke.

Rajani Sebastian, Sadhvi Saxena, Kyrana Tsapkini, Andreia V Faria, Charltien Long, Amy Wright, Cameron Davis, Donna C Tippett, Antonios P Mourdoukoutas, Marom Bikson and 2 more

2 registry-linked trialsAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in human neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03843463 phase2recruitingnot on this mapstarted 2021, after this paper: background citation

Escitalopram and Language Intervention for Subacute Aphasia (ELISA)

TypeinterventionalSponsorJohns Hopkins UniversityRan2021 to 2027Enrolled88ConditionsAphasia, StrokeArmsEscitalopram 10mg, Placebo, Computer-delivered naming treatment
NCT05093673 narecruitingnot on this mapstarted 2021, after this paper: background citation

Cerebellar Stimulation for Aphasia Rehabilitation

TypeinterventionalSponsorJohns Hopkins UniversityRan2021 to 2028Enrolled60ConditionsStrokeArmsCathodal Cerebellar tDCS, Semantic Feature Analysis (SFA), Sham
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Diagnosing and managing post-stroke aphasia.Expert review of neurotherapeutics · 2021
    Trial
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  19. Targeted neurorehabilitation strategies in post-stroke aphasia.Restorative neurology and neuroscience · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rajani SebastianDepartment of Neurology, Johns Hopkins University School of Medicine Baltimore, MD, USA.
Sadhvi SaxenaDepartment of Neurology, Johns Hopkins University School of Medicine Baltimore, MD, USA.
Kyrana TsapkiniDepartment of Neurology, Johns Hopkins University School of Medicine Baltimore, MD, USA.
Andreia V FariaDepartment of Radiology, Johns Hopkins University School of Medicine Baltimore, MD, USA.
Charltien LongDepartment of Neurology, Johns Hopkins University School of Medicine Baltimore, MD, USA.
Amy WrightDepartment of Neurology, Johns Hopkins University School of Medicine Baltimore, MD, USA.
Cameron DavisDepartment of Neurology, Johns Hopkins University School of Medicine Baltimore, MD, USA.
Donna C TippettDepartment of Neurology, Johns Hopkins University School of MedicineBaltimore, MD, USA; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of MedicineBaltimore, MD, USA.
Antonios P MourdoukoutasDepartment of Biomedical Engineering, The City College of New York of CUNY New York, NY, USA.
Marom BiksonDepartment of Biomedical Engineering, The City College of New York of CUNY New York, NY, USA.
Pablo CelnikDepartment of Neurology, Johns Hopkins University School of MedicineBaltimore, MD, USA; Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of MedicineBaltimore, MD, USA; Department of Neuroscience, Johns Hopkins University School of MedicineBaltimore, MD, USA.
Argye E HillisDepartment of Neurology, Johns Hopkins University School of MedicineBaltimore, MD, USA; Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of MedicineBaltimore, MD, USA; Department of Cognitive Science, Johns Hopkins UniversityBaltimore, MD, USA.

Funding

Telerehab for Aphasia (TERRA)P50DC014664 · NIDCD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI FRIDRIKSSON, JULIUS · 2016 to 2025
$25.0M
Neural Basis of Lexical Deficits in Hyperacute StrokeR01DC005375 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI Argye E. Hillis · 2002 to 2026
$11.8M
Effects of transcranial direct current stimulation in spoken and written production in primary progressive aphasiaR01DC014475 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI TSAPKINI, KYRANA · 2015 to 2019
$4.1M
Cerebellar Transcranial Direct Current Stimulation to Augment Chronic Aphasia TreatmentR00DC015554 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI SEBASTIAN, RAJANI · 2018 to 2020
$720k
Cerebellar Transcranial Direct Current Stimulation to Augment Chronic Aphasia TreatmentK99DC015554 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI SEBASTIAN, RAJANI · 2016 to 2017
$176k
NIDCD NIH HHS K99 DC015554NIDCD NIH HHS P50 DC014664NIDCD NIH HHS R00 DC015554NIDCD NIH HHS R01 DC005375NIDCD NIH HHS R01 DC014475
6 · The paper itself

Abstract

People with post-stroke aphasia may have some degree of chronic deficit for which current rehabilitative treatments are variably effective. Accumulating evidence suggests that transcranial direct current stimulation (tDCS) may be useful for enhancing the effects of behavioral aphasia treatment. However, it remains unclear which brain regions should be stimulated to optimize effects on language recovery. Here, we report on the therapeutic potential of right cerebellar tDCS in augmenting language recovery in SMY, who sustained bilateral MCA infarct resulting in aphasia and anarthria. We investigated the effects of 15 sessions of anodal cerebellar tDCS coupled with spelling therapy using a randomized, double-blind, sham controlled within-subject crossover trial. We also investigated changes in functional connectivity using resting state functional magnetic resonance imaging before and 2 months post-treatment. Both anodal and sham treatments resulted in improved spelling to dictation for trained and untrained words immediately after and 2 months post-treatment. However, there was greater improvement with tDCS than with sham, especially for untrained words. Further, generalization to written picture naming was only noted during tDCS but not with sham. The resting state functional connectivity data indicate that improvement in spelling was accompanied by an increase in cerebro-cerebellar network connectivity. These results highlight the therapeutic potential of right cerebellar tDCS to augment spelling therapy in an individual with large bilateral chronic strokes.

Indexed as

aphasiacerebellar tDCSresting state fMRIspelling therapystroke

Identifiers

PMID28127284
PMCPMC5226957

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.