ReviewCanadian respiratory journal2017
Mechanical Ventilation during Extracorporeal Membrane Oxygenation in Patients with Acute Severe Respiratory Failure.
Review in Canadian respiratory journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Oxygenated blood perfusion provides no additional benefit beyond flow control in lung ischemia-reperfusion injury.General thoracic and cardiovascular surgery · 2026Article
- The hospital length of stay and mortality and its risk and protective factors among patients with acute respiratory distress syndrome receiving extracorporeal membrane oxygenation: a systematic review and meta-analysis.Journal of thoracic disease · 2025Article
- A Computational Model of the Respiratory CPG for the Artificial Control of Breathing.Bioengineering (Basel, Switzerland) · 2025Article
- Extracorporeal Membrane Oxygenation in Burn Patients With Severe Inhalation Injuries: A Case Report.Cureus · 2025Article
- Article
- The road toward a physiological control of artificial respiration: the role of bio-inspired neuronal networks.Frontiers in neuroscience · 2025Article
- Current knowledge gaps in extracorporeal respiratory support.Intensive care medicine experimental · 2023Review
- COPD Exacerbation: Why It Is Important to Avoid ICU Admission.Journal of clinical medicine · 2023Review
- Implementation of Early Rehabilitation in Severe COVID-19 Respiratory Failure: A Scoping Review.Journal of acute care physical therapy · 2023Article
- Individualized Mechanical power-based ventilation strategy for acute respiratory failure formalized by finite mixture modeling and dynamic treatment regimen.EClinicalMedicine · 2021Article
- Article
- Extracorporeal membrane oxygenation and COVID-19: The causes of failure.Journal of cardiac surgery · 2020Article
- Awake extracorporeal membrane oxygenation in immunosuppressed patients with severe respiratory failure-a stretch too far?Journal of thoracic disease · 2019Article
- Application of Hybrid Extracorporeal Membrane Oxygenation for the Treatment of Subsequent Shock following Acute Respiratory Distress Syndrome Developing after Firearm Injury.Case reports in medicine · 2019Article
- Endotracheal tube clamping and extracorporeal membrane oxygenation to resuscitate massive pulmonary haemorrhage.Respirology case reports · 2018Article
- Outcomes of extracorporeal membrane oxygenation in adult patients with hypoxemic respiratory failure refractory to mechanical ventilation.Respiratory medicine case reports · 2018Article
- Respiratory Care for the Ventilated Neonate.Canadian respiratory journal · 2018Review
- The Role and Impact of Extracorporeal Membrane Oxygenation in Critical Care.Methodist DeBakey cardiovascular journalReview
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Conventionally, a substantial number of patients with acute respiratory failure require mechanical ventilation (MV) to avert catastrophe of hypoxemia and hypercapnia. However, mechanical ventilation per se can cause lung injury, accelerating the disease progression. Extracorporeal membrane oxygenation (ECMO) provides an alternative to rescue patients with severe respiratory failure that conventional mechanical ventilation fails to maintain adequate gas exchange. The physiology behind ECMO and its interaction with MV were reviewed. Next, we discussed the timing of ECMO initiation based on the risks and benefits of ECMO. During the running of ECMO, the protective ventilation strategy can be employed without worrying about catastrophic hypoxemia and carbon dioxide retention. There is a large body of evidence showing that protective ventilation with low tidal volume, high positive end-expiratory pressure, and prone positioning can provide benefits on mortality outcome. More recently, there is an increasing popularity on the use of awake and spontaneous breathing for patients undergoing ECMO, which is thought to be beneficial in terms of rehabilitation.
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