Evidence map›Paper›PMID 28127210›Full record

ReviewWorld journal of gastroenterology2017

Vanishing bile duct syndrome in Hodgkin's lymphoma: A case report and literature review.

Mena Bakhit, Thomas R McCarty, Sunhee Park, Basile Njei, Margaret Cho, Raffi Karagozian, AnnMarie Liapakis

Open access · hybridAbstract readCase ReportsReview
In one paragraph

Review in World journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 58 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review of Paraneoplastic Syndromes in Children with Malignancy.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Acquired ductopenia: an insight into imaging findings.Abdominal radiology (New York) · 2025
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Mena BakhitMena Bakhit, Thomas R McCarty, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, United States.
Thomas R McCartyMena Bakhit, Thomas R McCarty, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, United States.
Sunhee ParkMena Bakhit, Thomas R McCarty, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, United States.
Basile NjeiMena Bakhit, Thomas R McCarty, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, United States.
Margaret ChoMena Bakhit, Thomas R McCarty, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, United States.
Raffi KaragozianMena Bakhit, Thomas R McCarty, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, United States.
AnnMarie LiapakisMena Bakhit, Thomas R McCarty, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, United States.
Saint Francis Hospital · USSaint Francis University · USYale University · USHartford Financial Services (United States)

Funding

Training Program in Investigative HepatologyT32DK007356 · NIDDK · YALE UNIVERSITY · PI MICHAEL H NATHANSON · 1986 to 2026
$7.4M
6 · The paper itself

Abstract

Vanishing bile duct syndrome (VBDS) has been described in different pathologic conditions including infection, ischemia, adverse drug reactions, autoimmune diseases, allograft rejection, and humoral factors associated with malignancy. It is an acquired condition characterized by progressive destruction and loss of the intra-hepatic bile ducts leading to cholestasis. Prognosis is variable and partially dependent upon the etiology of bile duct injury. Irreversible bile duct loss leads to significant ductopenia, biliary cirrhosis, liver failure, and death. If biliary epithelial regeneration occurs, clinical recovery may occur over a period of months to years. VBDS has been described in a number of cases of patients with Hodgkin's lymphoma (HL) where it is thought to be a paraneoplastic phenomenon. This case describes a 25-year-old man found on liver biopsy to have VBDS. Given poor response to medical treatment, the patient underwent transplant evaluation at that time and was found to have classical stage IIB HL. Early recognition of this underlying cause or association of VBDS, including laboratory screening, and physical exam for lymphadenopathy are paramount to identifying potential underlying VBDS-associated malignancy. Here we review the literature of HL-associated VBDS and report a case of diagnosed HL with biopsy proven VBDS.

Indexed as

AdultAntineoplastic AgentsBile Duct DiseasesBile Ducts, IntrahepaticBiopsyCholangiopancreatography, Magnetic ResonanceCholestasisExomeHepatocyte Growth FactorHigh-Throughput Nucleotide SequencingHodgkin DiseaseHumansHyperbilirubinemiaHypertension, PortalJaundiceLiverAntineoplastic AgentsHepatocyte Growth Factormacrophage stimulating proteinProto-Oncogene ProteinsBile ductopeniaCholestasisHodgkin’s lymphomaLiverVanishing bile duct syndrome

Identifiers

PMID28127210
PMCPMC5236516
OpenAlexW2576344121

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.