Evidence map›Paper›PMID 28127195›Full record

ArticleWorld journal of gastroenterology2017

SPECT-computed tomography in rats with TNBS-induced colitis: A first step toward functional imaging.

Rachel Marion-Letellier, Pierre Bohn, Romain Modzelewski, Pierre Vera, Moutaz Aziz, Charlène Guérin, Guillaume Savoye, Céline Savoye-Collet

Open access · hybridAbstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Rachel Marion-LetellierRachel Marion-Letellier, Charlène Guérin, Guillaume Savoye, INSERM Unit UMR1073, Rouen University and Rouen University Hospital, 76183 Rouen, France.
Pierre BohnRachel Marion-Letellier, Charlène Guérin, Guillaume Savoye, INSERM Unit UMR1073, Rouen University and Rouen University Hospital, 76183 Rouen, France.
Romain ModzelewskiRachel Marion-Letellier, Charlène Guérin, Guillaume Savoye, INSERM Unit UMR1073, Rouen University and Rouen University Hospital, 76183 Rouen, France.
Pierre VeraRachel Marion-Letellier, Charlène Guérin, Guillaume Savoye, INSERM Unit UMR1073, Rouen University and Rouen University Hospital, 76183 Rouen, France.
Moutaz AzizRachel Marion-Letellier, Charlène Guérin, Guillaume Savoye, INSERM Unit UMR1073, Rouen University and Rouen University Hospital, 76183 Rouen, France.
Charlène GuérinRachel Marion-Letellier, Charlène Guérin, Guillaume Savoye, INSERM Unit UMR1073, Rouen University and Rouen University Hospital, 76183 Rouen, France.
Guillaume SavoyeRachel Marion-Letellier, Charlène Guérin, Guillaume Savoye, INSERM Unit UMR1073, Rouen University and Rouen University Hospital, 76183 Rouen, France.
Céline Savoye-ColletRachel Marion-Letellier, Charlène Guérin, Guillaume Savoye, INSERM Unit UMR1073, Rouen University and Rouen University Hospital, 76183 Rouen, France.
Centre Hospitalier Universitaire de Rouen · FRInstitut d'Imagerie Biomédicale · FRUniversité de Rouen Normandie · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo assess the feasibility of SPECT-computed tomography (CT) in rats with trinitrobenzene sulfonic acid (TNBS)-induced acute colitis and confront it with model inflammatory characteristics.

methodsColitis was induced in Sprague-Dawley rats by intrarectal injection of TNBS (

resultsColon weight/length ratio, colon COX-2 expression and histological inflammatory score were significantly higher in the TNBS group than in the control group (

conclusionSPECT-CT is feasible and easily distinguished control from colitic rats.

Indexed as

Tomography, Emission-Computed, Single-PhotonAnimalsBlotting, WesternCitratesColitisColonCrohn DiseaseCyclooxygenase 2Disease Models, AnimalFeasibility StudiesGalliumMaleRadiopharmaceuticalsRatsRats, Sprague-DawleyTrinitrobenzenesulfonic AcidCitratesCyclooxygenase 2Galliumgallium citratePtgs2 protein, ratRadiopharmaceuticalsTrinitrobenzenesulfonic AcidColitisColitis imagingCrohn’s diseaseCyclooxygenase-2SPECT-computed tomography

Identifiers

PMID28127195
PMCPMC5236501
OpenAlexW2576410186

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.