Evidence map›Paper›PMID 28126903›Full record

ArticleThe Journal of biological chemistry2017

The Significance of the Bifunctional Kinase/Phosphatase Activities of Diphosphoinositol Pentakisphosphate Kinases (PPIP5Ks) for Coupling Inositol Pyrophosphate Cell Signaling to Cellular Phosphate Homeostasis.

Chunfang Gu, Hoai-Nghia Nguyen, Alexandre Hofer, Henning J Jessen, Xuming Dai, Huanchen Wang, Stephen B Shears

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 83 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Oncometabolite 5-IPNature chemical biology · 2026
    Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Transport and InsPNature communications · 2025
    Article
  17. Article
  18. Evolution of phosphate scouting in the terrestrial biosphere.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Chunfang GuFrom the Laboratory of Signal Transduction, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina, 27709.
Hoai-Nghia NguyenFrom the Laboratory of Signal Transduction, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina, 27709.
Alexandre HoferDepartment of Chemistry, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.
Henning J JessenInstitute of Organic Chemistry, Albert Ludwigs University, Albertstrasse 21, 79104 Freiburg, Germany, and.
Xuming DaiDivision of Cardiology, McAllister Heart Institute, University of North Carolina, Chapel Hill, North Carolina 27599.
Huanchen WangFrom the Laboratory of Signal Transduction, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina, 27709.
Stephen B ShearsFrom the Laboratory of Signal Transduction, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina, 27709, shears@niehs.nih.gov.
National Institutes of Health · USNational Institute of Environmental Health Sciences · USUniversity of Freiburg · DEUniversity of North Carolina at Chapel Hill · USUniversity of Zurich · CH

Funding

North Carolina Translational & Clinical Sciences Institute (NC TraCS)UL1TR001111 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, CAREY, TIMOTHY S · 2013 to 2017
$43.9M
Inositol SignallingZIAES080046 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SHEARS, STEPHEN B · 2009 to 2023
$31.3M
NCATS NIH HHS UL1 TR001111
6 · The paper itself

Abstract

Proteins responsible for P

Indexed as

Signal TransductionAcid Anhydride HydrolasesAdenosine TriphosphateHCT116 CellsHEK293 CellsHomeostasisHumansInositol PhosphatesPhosphotransferases (Phosphate Group Acceptor)1-diphosphoinositol pentakisphosphateAcid Anhydride HydrolasesAdenosine Triphosphatediphosphoinositol polyphosphate phosphohydrolaseinositol-1-pyrophosphateInositol PhosphatesPhosphotransferases (Phosphate Group Acceptor)PPIP5K1 protein, humanPPIP5K2 protein, humaninositol phosphatemetabolismphosphatasesignalingsignal transduction

Identifiers

PMID28126903
PMCPMC5377771
OpenAlexW2579897106

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.