ArticleThe Journal of experimental medicine2017
ERBIN deficiency links STAT3 and TGF-β pathway defects with atopy in humans.
Erratum issuedOpen access · bronzeAbstract read
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Article in The Journal of experimental medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 57 papers.
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57citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
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Who cites it
57 citing papers in PubMed, 97 citations in OpenAlex.
- Losartan Treatment Reduces Esophageal Eosinophilic Inflammation in a Subset of Eosinophilic Esophagitis.The journal of allergy and clinical immunology. In practice · 2024Trial
- Clinical features, genetics, treatment, and long-term outcomes of STAT3 hyper-IgE syndrome: Single-center cohort analysis.The Journal of allergy and clinical immunology · 2026Observational
- Oncostatin M receptor deficiency as a novel candidate genetic cause of autosomal recessive hyper-IgE syndrome.Journal of human immunity · 2026Article
- Immune functions of the esophagus.The Journal of allergy and clinical immunology · 2026Review
- Atopic dermatitis in inborn errors of immunity: at the interface of immunodeficiency and immune dysregulation.Immunologic research · 2025Review
- Pathological IgE Production in Inborn Errors of Immunity and Beyond.Immunological reviews · 2025Review
- Pulmonary features and stage of disease in adult patients with hyper-IgE syndrome: a single-centre clinical study and literature review.Orphanet journal of rare diseases · 2025Article
- Inborn errors of immunity with atopic phenotypes in the allergy and immunology clinic: a practical review.Current opinion in allergy and clinical immunology · 2025Review
- Hyper IgE Syndromes: Understanding, Management, and Future Perspectives: A Narrative Review.Health science reports · 2025Article
- Inborn Errors of Immunity Presenting with Early-Onset Severe Atopy.Medicina (Kaunas, Lithuania) · 2025Review
- Understanding and Managing Hyper IgE Syndromes.ImmunoTargets and therapy · 2025Review
- The genetics of hyper IgE syndromes.Frontiers in immunology · 2025Review
- Cytokine signaling defects in primary atopic diseases-an updated review.Frontiers in allergy · 2025Review
- Phenotypes of 126 Moroccan HIES patients according to NIH Score.La Tunisie medicale · 2024Article
- Insights into the clinical, immunologic, and genetic underpinnings of food allergy.Immunological reviews · 2024Review
- TThe Journal of allergy and clinical immunology · 2024Review
- Overlap of eosinophilic esophagitis with inborn errors of immunity and immune dysregulation.The Journal of allergy and clinical immunology · 2024Article
- Inborn errors of immunity with susceptibility toFrontiers in pediatrics · 2024Review
- Article
- ERBIN and phosphoglucomutase 3 deficiency.Current opinion in immunology · 2023Review
Corrections and comments
- Erratum issued
Authors and funding
25 authors at 6 institutions in 2 countries.
J J LyonsGenetics and Pathogenesis of Allergy Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.ORCID 0000-0002-2346-8189
Y LiuGenetics and Pathogenesis of Allergy Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
C A MaGenetics and Pathogenesis of Allergy Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
X YuGenetics and Pathogenesis of Allergy Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.ORCID 0000-0002-6981-5772
M P O'ConnellGenetics and Pathogenesis of Allergy Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
M G LawrenceDivision of Asthma, Allergy, and Immunology, Department of Medicine, University of Virginia, Charlottesville, VA 22903.
Y ZhangGenetics and Pathogenesis of Allergy Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.ORCID 0000-0001-9932-917X
K KarpeGenetics and Pathogenesis of Allergy Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
M ZhaoResearch Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.ORCID 0000-0002-5700-2950
A M SiegelGenetics and Pathogenesis of Allergy Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.ORCID 0000-0003-4913-570X
K D StoneGenetics and Pathogenesis of Allergy Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
C NelsonGenetics and Pathogenesis of Allergy Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
N JonesClinical Research Directorate/CRMP, Leidos Biomedical Research Inc., NCI Campus at Frederick, Frederick, MD 21702.ORCID 0000-0003-3382-5589
T DiMaggioGenetics and Pathogenesis of Allergy Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
D N DarnellLaboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
E Mendoza-CaamalNational Institute of Genomic Medicine, 14610 Mexico City, Mexico.ORCID 0000-0002-6224-6829
L OrozcoNational Institute of Genomic Medicine, 14610 Mexico City, Mexico.ORCID 0000-0002-5801-9180
J D HughesMerck Research Laboratories, Merck & Co. Inc., Boston, MA 02115.ORCID 0000-0002-8965-5382
J McElweeMerck Research Laboratories, Merck & Co. Inc., Boston, MA 02115.ORCID 0000-0002-4888-7152
R J HohmanResearch Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.ORCID 0000-0003-0178-0494
P A Frischmeyer-GuerrerioFood Allergy Research Unit, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
M E RothenbergDivision of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.
A F FreemanLaboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.ORCID 0000-0001-7005-8345
S M HollandLaboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
J D MilnerGenetics and Pathogenesis of Allergy Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 jdmilner@niaid.nih.gov.ORCID 0000-0002-3913-3869
National Institutes of Health · USMerck & Co., Inc., Rahway, NJ, USA (United States) · USNational Institute of Genomic Medicine · MXCincinnati Children's Hospital Medical Center · USLeidos (United States) · USUniversity of Virginia · US
Funding
Infectious Diseases Research Technologies Core - BethesdaZICAI001051 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI CHERRY, JAMES · 2009 to 2025
$226.1MTranslational studies in allergic reactions and inflammationZIAAI001192 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI LYONS, JONATHAN · 2014 to 2023
$12.7MThe Role of Transforming Growth Factor Beta (TGFbeta) in Promoting Allergic InflammationZIAAI001203 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI FRISCHMEYER-GUERRERIO, PAMELA · 2015 to 2025
$10.6MGenetic and Pathophysiologic Study of Atopic DiseaseZIAAI001183 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MILNER, JOSHUA · 2013 to 2019
$8.7MCCR NIH HHS HHSN261200800001CNCI NIH HHS HHSN261200800001E
Abstract
Nonimmunological connective tissue phenotypes in humans are common among some congenital and acquired allergic diseases. Several of these congenital disorders have been associated with either increased TGF-β activity or impaired STAT3 activation, suggesting that these pathways might intersect and that their disruption may contribute to atopy. In this study, we show that STAT3 negatively regulates TGF-β signaling via ERBB2-interacting protein (ERBIN), a SMAD anchor for receptor activation and SMAD2/3 binding protein. Individuals with dominant-negative
Indexed as
Adaptor Proteins, Signal TransducingHumansHypersensitivityInterleukin-4Receptors, Interleukin-4Signal TransductionSmad2 ProteinSmad3 ProteinSTAT3 Transcription FactorTransforming Growth Factor betaAdaptor Proteins, Signal TransducingERBIN protein, humanInterleukin-4Receptors, Interleukin-4Smad2 ProteinSMAD2 protein, humanSmad3 ProteinSMAD3 protein, humanSTAT3 protein, humanSTAT3 Transcription FactorTransforming Growth Factor beta
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.