Evidence map›Paper›PMID 28126746›Full record

ArticleAJNR. American journal of neuroradiology2017

Genetically Defined Oligodendroglioma Is Characterized by Indistinct Tumor Borders at MRI.

D R Johnson, F E Diehn, C Giannini, R B Jenkins, S M Jenkins, I F Parney, T J Kaufmann

Open access · hybridAbstract read
In one paragraph

Article in AJNR. American journal of neuroradiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 2 pooled it
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 74 citations in OpenAlex.

  1. Pooled it
  2. Noninvasive Determination ofAJNR. American journal of neuroradiology · 2021
    Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. A rare, giant, anaplastic oligodendroglioma.Radiology case reports · 2023
    Article
  13. Article
  14. Article
  15. Review
  16. Imaging diagnosis and treatment selection for brain tumors in the era of molecular therapeutics.Cancer imaging : the official publication of the International Cancer Imaging Society · 2022
    Review
  17. Grading of adult diffuse gliomas according to the 2021 WHO Classification of Tumors of the Central Nervous System.Laboratory investigation; a journal of technical methods and pathology · 2022
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

D R JohnsonFrom the Departments of Radiology (D.R.J., F.E.D., T.J.K.).ORCID 0000-0002-4217-5517
F E DiehnFrom the Departments of Radiology (D.R.J., F.E.D., T.J.K.).ORCID 0000-0001-9458-8017
C GianniniPathology (C.G., R.B.J.).ORCID 0000-0003-2757-6782
R B JenkinsPathology (C.G., R.B.J.).ORCID 0000-0002-4049-694X
S M JenkinsHealth Sciences Research (S.M.J.).ORCID 0000-0002-4157-8066
I F ParneyNeurosurgery (I.F.P.), Mayo Clinic, Rochester, Minnesota.ORCID 0000-0002-9702-8047
T J KaufmannFrom the Departments of Radiology (D.R.J., F.E.D., T.J.K.) Kaufmann.Timothy@mayo.edu.ORCID 0000-0001-7483-1569
Jisc · GBM4 Sciences (United States) · USMayo Clinic · USMayo Clinic in Arizona · US

Funding

Targeted MV-CEA as a Potent Antitumor Agent against GBMP50CA108961 · NCI · MAYO CLINIC ROCHESTER · PI O'NEILL, BRIAN PATRICK · 2004 to 2015
$22.5M
NCI NIH HHS P50 CA108961
6 · The paper itself

Abstract

background and purposeIn 2016, the World Health Organization revised the brain tumor classification, making MATERIALS AND

methodsOne hundred forty-eight adult patients with untreated World Health Organization grade II and III infiltrating gliomas with histologic oligodendroglial morphology, known 1p/19q status, and at least 1 preoperative MR imaging were retrospectively identified. The association of 1p/19q codeletion with tumor imaging characteristics and ADC values was evaluated.

resultsNinety of 148 (61%) patients had 1p/19q codeleted tumors, corresponding to genetically defined oligodendroglioma, and 58/148 (39%) did not show 1p/19q codeletion, corresponding to astrocytic tumors. Eighty-three of 90 (92%) genetically defined oligodendrogliomas had noncircumscribed borders, compared with 26/58 (45%) non-1p/19q codeleted tumors with at least partial histologic oligodendroglial morphology (

conclusionsImaging characteristics of World Health Organization 2016 genetically defined oligodendrogliomas differ from the previously considered characteristics of morphologically defined oligodendrogliomas. We found that genetically defined oligodendrogliomas were commonly poorly circumscribed and were almost always heterogeneous in signal intensity.

Indexed as

AdultAgedBrain NeoplasmsChromosomes, Human, Pair 1Chromosomes, Human, Pair 19FemaleHumansIsocitrate DehydrogenaseMagnetic Resonance ImagingMaleMiddle AgedMutationOligodendrogliomaRetrospective StudiesIsocitrate Dehydrogenase

Identifiers

PMID28126746
PMCPMC7960254
OpenAlexW2580208371

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.