Evidence map›Paper›PMID 28126650›Full record

ReviewCurrent opinion in genetics & development2017

Recent progress in single-cell cancer genomics.

Daphne Tsoucas, Guo-Cheng Yuan

Abstract readReview
In one paragraph

Review in Current opinion in genetics & development, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Single Cell Self-Paced Clustering with Transcriptome Sequencing Data.International journal of molecular sciences · 2022
    Article
  7. Pollock: fishing for cell states.Bioinformatics advances · 2022
    Article
  8. Review
  9. Population mutation properties of tumor evolution.Medical oncology (Northwood, London, England) · 2020
    Article
  10. Article
  11. Review
  12. Article
  13. Single-Cell Applications of Next-Generation Sequencing.Cold Spring Harbor perspectives in medicine · 2019
    Review
  14. Article
  15. Article
  16. Next-Generation Sequencing Strategies.Cold Spring Harbor perspectives in medicine · 2019
    Review
  17. Article
  18. Single Cell Omics of Breast Cancer: An Update on Characterization and Diagnosis.Indian journal of clinical biochemistry : IJCB · 2019
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Daphne TsoucasDepartment of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Guo-Cheng YuanDepartment of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. Electronic address: gcyuan@jimmy.harvard.edu.

Funding

Statistical Methods for Analysis of Massive Genetic and Genomic Data in Cancer ResearchR35CA197449 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI XIHONG LIN · 2015 to 2026
$10.9M
Transcriptional control of gut epithelial homeostasis and regenerationR01DK081113 · NIDDK · DANA-FARBER CANCER INST · PI SHIVDASANI, RAMESH A · 2009 to 2022
$5.6M
Joint Interdisciplinary Training Program in Biostatistics & Computational BiologyT32GM074897 · NIGMS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI HUTTENHOWER, CURTIS, LIN, XIHONG · 2005 to 2019
$3.7M
Systems Biology Analysis of Human ErythropoiesisR01HL119099 · NHLBI · DANA-FARBER CANCER INST · PI ORKIN, STUART H, YUAN, GUO-CHENG · 2014 to 2018
$3.4M
Conferences on Emerging Statistical Issues in Biomedical ResearchR13CA124365 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI LIN, XIHONG · 2006 to 2015
$262k
NCI NIH HHS R13 CA124365NCI NIH HHS R35 CA197449NHLBI NIH HHS R01 HL119099NIDDK NIH HHS R01 DK081113NIGMS NIH HHS T32 GM074897
6 · The paper itself

Abstract

The advent of single-cell sequencing has been revolutionary to the field of cancer genomics. Perfectly suited to capture cancer's heterogeneous nature, single-cell analyses provide information bulk sequencing could never hope to uncover. Many mechanisms of cancer have yet to be fully understood, and single-cell approaches are showing promise in their abilities to uncover these mysteries. Here we focus on the most recent single-cell methods for cancer genomics, and how they are not only providing insights into the inner workings of cancer, but are also transforming individualized therapy and non-invasive monitoring and diagnosis.

Indexed as

GenomicsHigh-Throughput Nucleotide SequencingHumansNeoplasmsSingle-Cell Analysis

Identifiers

PMID28126650
PMCPMC5446798

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.