ArticleActa biomaterialia2017
Tuning cell adhesive properties via layer-by-layer assembly of chitosan and alginate.
Article in Acta biomaterialia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed.
- Breast cancer extracellular matrix invasion depends on local mechanical loading of the collagen network.Journal of materials chemistry. B · 2025Article
- 3D Printing-Based Hydrogel Dressings for Wound Healing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Chitosan-Based Biomaterials: Insights into Chemistry, Properties, Devices, and Their Biomedical Applications.Marine drugs · 2023Review
- Unveiling the Assembly of Neutral Marine Polysaccharides into Electrostatic-Driven Layer-by-Layer Bioassemblies by Chemical Functionalization.Marine drugs · 2023Article
- Engineering alginate hydrogel films with poly(3-hydroxybutyrate-co-3-valerate) and graphene nanoplatelets: Enhancement of antiviral activity, cell adhesion and electroactive properties.International journal of biological macromolecules · 2022Article
- Preparation and Properties of Blended Composite Film Manufactured Using Walnut-Peptide-Chitosan-Sodium Alginate.Foods (Basel, Switzerland) · 2022Article
- Critical adhesion areas of cells on micro-nanopatterns.Nano research · 2022Article
- Layer-by-Layer Fabrication of PAH/PAMAM/Nano-CaCOInternational journal of biomaterials · 2022Article
- Green approaches for extraction, chemical modification and processing of marine polysaccharides for biomedical applications.Frontiers in bioengineering and biotechnology · 2022Review
- Polyelectrolyte Gels: Fundamentals, Fabrication and Applications.Gels (Basel, Switzerland) · 2021Review
- Polyelectrolyte Multilayer Films Based on Natural Polymers: From Fundamentals to Bio-Applications.Polymers · 2021Review
- Improved Osteogenesis by Mineralization Combined With Double-Crosslinked Hydrogel Coating for Proliferation and Differentiation of Mesenchymal Stem Cells.Frontiers in bioengineering and biotechnology · 2021Article
- QCM-D assay for quantifying the swelling, biodegradation, and protein adsorption of intelligent nanogels.Journal of applied polymer science · 2020Article
- Study of 1D and 2D Carbon Nanomaterial in Alginate Films.Nanomaterials (Basel, Switzerland) · 2020Article
- Novel cationic tannin/glycosaminoglycan-based polyelectrolyte multilayers promote stem cells adhesion and proliferation.RSC advances · 2019Article
- Biomimetic Layer-by-Layer Self-Assembly of Nanofilms, Nanocoatings, and 3D Scaffolds for Tissue Engineering.International journal of molecular sciences · 2018Review
- Three-DimensionalFrontiers in pharmacology · 2018Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Understanding the mechanisms controlling cell-multilayer film interactions is crucial to the successful engineering of these coatings for biotechnological and biomedical applications. Herein, we present a strategy to tune the cell adhesive properties of multilayers based on marine polysaccharides with and without cross-linking and/or coating with extracellular matrix proteins. Chemical cross-linking of multilayers improved mechanical properties of the coatings but also elicited changes in surface chemistry that alter the adhesion of human umbilical vein endothelial cells. We evaluated a strategy to decouple the mechanical and chemical properties of these films, enabling the transition from cell-adhesive to cell-resistant multilayers. Addition of chitosan/alginate multilayers on top of cross-linked films decreased endothelial cell adhesion, spreading, and proliferation to similar levels as uncross-linked films. Our findings highlight the key role of surface chemistry in cell-multilayer film interactions, and these engineered nanocoatings represent a tunable model of cell adhesive and non-adhesive multilayered films. STATEMENT OF SIGNIFICANCE: Multilayered films based on marine-derived polysaccharides were obtained by layer-by-layer (LbL). Biological tests with human umbilical vein endothelial cells (HUVECs) showed the potential of these films to tailor cell adhesion, spreading and proliferation. These multilayered films promise to be versatile and tunable model of cell adhesive and non-adhesive films.
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Registered trials
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