Evidence map›Paper›PMID 28126543›Full record

ReviewMolecular and biochemical parasitology2017

Lessons from the genomes and transcriptomes of filarial nematodes.

Alexandra Grote, Sara Lustigman, Elodie Ghedin

Abstract readReview
In one paragraph

Review in Molecular and biochemical parasitology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Heartworm disease - Overview, intervention, and industry perspective.International journal for parasitology. Drugs and drug resistance · 2021
    Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alexandra GroteCenter for Genomics and Systems Biology, Department of Biology, New York University, USA.
Sara LustigmanMolecular Parasitology, New York Blood Center, USA.
Elodie GhedinCenter for Genomics and Systems Biology, Department of Biology, New York University, USA. Electronic address: elodie.ghedin@nyu.edu.

Funding

INFECTIOUS DISEASES &BASIC MICROBIOLOGICAL MECHANISMST32AI007180 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI WEISER, JEFFREY NEAL · 1985 to 2022
$8.9M
Functional interplay between Brugia and its Wolbachia symbiontR56AI118936 · NIAID · NEW YORK BLOOD CENTER · PI GHEDIN, ELODIE, LUSTIGMAN, SARA · 2016 to 2016
$770k
NIAID NIH HHS R56 AI118936NIAID NIH HHS T32 AI007180
6 · The paper itself

Abstract

Human filarial infections are a leading cause of morbidity in the developing world. While a small arsenal of drugs exists to treat these infections, there remains a tremendous need for the development of additional interventions. Recent genome sequences and transcriptome analyses of filarial nematodes have provided novel biological insight and allowed for the prediction of novel drug targets as well as potential vaccine candidates. In this review, we discuss the currently available data, insights gained into the metabolism of these organisms, and how the filaria field can move forward by leveraging these data.

Indexed as

Genome, HelminthTranscriptomeAnimalsDrug DiscoveryFilarioideaGenetic Association StudiesHumansMetabolic Networks and PathwaysFilariaGenomicsParasitic nematodesTranscriptomics

Identifiers

PMID28126543
PMCPMC5474361

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.