ArticleMatrix biology : journal of the International Society for Matrix Biology2017
HS3ST1 genotype regulates antithrombin's inflammomodulatory tone and associates with atherosclerosis.
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Article in Matrix biology : journal of the International Society for Matrix Biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- CRISPR activation screens identify core protein-dependent regulation of heparan sulfate sulfation and ligand specificity.bioRxiv : the preprint server for biology · 2026Article
- Development and experimental verification of a prognosis model for hypoxia- and lactate metabolism-associated genes in HNSCC.Medicine · 2025Article
- THE INTERACTION BETWEEN ANTITHROMBIN AND ENDOTHELIAL HEPARAN SULFATE MITIGATES PULMONARY THROMBOINFLAMMATION AFTER TRAUMA AND HEMORRHAGIC SHOCK.Shock (Augusta, Ga.) · 2025Article
- Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation.Nature communications · 2024Article
- A 3-Frontiers in immunology · 2023Article
- Alterations in heparan sulfate proteoglycan synthesis and sulfation and the impact on vascular endothelial function.Matrix biology plus · 2022Review
- Validation of Polygenic Risk Scores for Coronary Heart Disease in a Middle Eastern Cohort Using Whole Genome Sequencing.Circulation. Genomic and precision medicine · 2022Article
- Emerging chemical and biochemical tools for studying 3-American journal of physiology. Cell physiology · 2022Review
- A novel seven-gene risk profile in BALF to identify high-risk patients with idiopathic pulmonary fibrosis.Journal of thoracic disease · 2022Article
- Physiology and Pathophysiology of Heparan Sulfate in Animal Models: Its Biosynthesis and Degradation.International journal of molecular sciences · 2022Review
- Article
- The Prognostic Value of Integrated Analysis of Inflammation and Hypoxia-Related Genes in Idiopathic Pulmonary Fibrosis.Frontiers in immunology · 2022Article
- Loss of Hs3st3a1 or Hs3st3b1 enzymes alters heparan sulfate to reduce epithelial morphogenesis and adult salivary gland function.Matrix biology : journal of the International Society for Matrix Biology · 2021Article
- Article
- Article
- The heparan sulfate proteoglycan grip on hyperlipidemia and atherosclerosis.Matrix biology : journal of the International Society for Matrix Biology · 2018Review
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 2 countries.
Nicole C SmitsSection of Cardiology, Department of Medicine, Heart and Vascular Center, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
Takashi KobayashiSection of Cardiology, Department of Medicine, Heart and Vascular Center, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
Pratyaksh K SrivastavaSection of Cardiology, Department of Medicine, Heart and Vascular Center, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
Sladjana SkopeljaSection of Cardiology, Department of Medicine, Heart and Vascular Center, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
Julianne A IvySection of Cardiology, Department of Medicine, Heart and Vascular Center, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
Dustin J ElwoodDepartment of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Radu V StanDepartment of Pathology, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
Gregory J TsongalisDepartment of Pathology, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
Frank W SellkeDivision of Cardiothoracic Surgery, Brown Medical School, Providence, RI, USA.
Peter L GrossDepartment of Medicine, Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, Ontario, Canada.
Michael D ColeDepartment of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH, USA; Department of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
James T DeVriesSection of Cardiology, Department of Medicine, Heart and Vascular Center, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
Aaron V KaplanSection of Cardiology, Department of Medicine, Heart and Vascular Center, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
John F RobbSection of Cardiology, Department of Medicine, Heart and Vascular Center, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
Scott M WilliamsDepartment of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Nicholas W ShworakSection of Cardiology, Department of Medicine, Heart and Vascular Center, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA; Department of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA. Electronic address: nshw@gwu.edu.
Dartmouth–Hitchcock Medical Center · USDartmouth College · USBrown University · USThrombosis and Atherosclerosis Research Institute · CA
Funding
Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Steven D Leach · 1985 to 2026
$91.3MFUNCTION OF THE C-MYC ONCOGENER01CA055248 · NCI · PRINCETON UNIVERSITY · PI COLE, MICHAEL DAVID · 1992 to 2020
$8.6MQuantitative Biology Research InstituteP20GM103534 · NIGMS · DARTMOUTH COLLEGE · PI AMOS, CHRISTOPHER I. · 2012 to 2016
$8.6MEffect of Cardioplegia and Cardiopulmonary Bypass on Coronary Microvascular ReactivityR01HL046716 · NHLBI · RHODE ISLAND HOSPITAL · PI SELLKE, FRANK W · 1997 to 2023
$8.5MVascular Dysfunction in Myocardial Ischemia and Metabolic SyndromeR01HL128831 · NHLBI · RHODE ISLAND HOSPITAL · PI SELLKE, FRANK W, USHEVA-SIMIDJIYSKA, ANNY · 2016 to 2025
$5.7MBioinformatics Strategies for Genome-Wide Association StudiesR01LM010098 · NLM · UNIVERSITY OF PENNSYLVANIA · PI MOORE, JASON H., WILLIAMS, SCOTT MATTHEW · 2009 to 2023
$5.1M3-OST-1 Regulation of Antithrombin Isoform PartitioningR01HL079104 · NHLBI · DARTMOUTH COLLEGE · PI SHWORAK, NICHOLAS W · 2006 to 2009
$1.8MMechanism of fenestrae assembly in mammalian endothelial cellsR01GM120592 · NIGMS · DARTMOUTH COLLEGE · PI STAN, RADU VIRGIL · 2016 to 2019
$1.3M3OST1 Deficiency and Cardiovascular DiseaseR01AG023590 · NIA · DARTMOUTH COLLEGE · PI SHWORAK, NICHOLAS W · 2005 to 2008
$985kAnti-PV1 Therapy for Pancreatic CancerR21CA172983 · NCI · DARTMOUTH COLLEGE · PI CARRIERE, CATHERINE, STAN, RADU VIRGIL · 2013 to 2014
$382kPlasmalemma vesicle-associated protein (PV-1) as a novel target in cancer immunotR21CA175592 · NCI · DARTMOUTH COLLEGE · PI STAN, RADU VIRGIL · 2013 to 2014
$382kVevo 770 for Ultrasound BiomicroscopyS10RR023436 · NCRR · DARTMOUTH COLLEGE · PI SHWORAK, NICHOLAS W · 2007 to 2007
$352kNCI NIH HHS P30 CA023108NCI NIH HHS R01 CA055248NCI NIH HHS R21 CA172983NCI NIH HHS R21 CA175592NCRR NIH HHS S10 RR023436NHLBI NIH HHS R01 HL046716NHLBI NIH HHS R01 HL079104NHLBI NIH HHS R01 HL128831NIA NIH HHS R01 AG023590NIGMS NIH HHS P20 GM103534NIGMS NIH HHS R01 GM120592NIH HHS S10 OD010330NLM NIH HHS R01 LM010098
Abstract
The HS3ST1 gene controls endothelial cell production of HS
Indexed as
AnimalsAntithrombinsAtherosclerosisCarotid Artery DiseasesFemaleGenetic Association StudiesGenotypeHumansImmunomodulationLinkage DisequilibriumLipopolysaccharidesMaleMice, 129 StrainMice, Inbred C57BLMice, KnockoutPolymorphism, Single NucleotideAntithrombinsheparitin sulfotransferaseLipopolysaccharidesSulfotransferasesTumor Necrosis Factor-alpha3-O-sulfotransferaseAtherosclerosisHeparan sulfateHS3ST1InflammationSepsis
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.