Evidence map›Paper›PMID 28126518›Full record

ArticleBioorganic & medicinal chemistry letters2017

Synthesis, characterization, in vitro SAR and in vivo evaluation of N,N'bisnaphthylmethyl 2-alkyl substituted imidazolium salts against NSCLC.

Michael A DeBord, Marie R Southerland, Patrick O Wagers, Kristin M Tiemann, Nikki K Robishaw, Kyle T Whiddon, Michael C Konopka, Claire A Tessier, Leah P Shriver, Sailaja Paruchuri and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Michael A DeBordDepartment of Chemistry, University of Akron, Akron, OH 44325, United States.
Marie R SoutherlandDepartment of Chemistry, University of Akron, Akron, OH 44325, United States.
Patrick O WagersDepartment of Chemistry, University of Akron, Akron, OH 44325, United States.
Kristin M TiemannDepartments of Pediatrics and Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, United States.
Nikki K RobishawDepartment of Chemistry, University of Akron, Akron, OH 44325, United States.
Kyle T WhiddonDepartment of Chemistry, University of Akron, Akron, OH 44325, United States.
Michael C KonopkaDepartment of Chemistry, University of Akron, Akron, OH 44325, United States.
Claire A TessierDepartment of Chemistry, University of Akron, Akron, OH 44325, United States.
Leah P ShriverDepartment of Chemistry, University of Akron, Akron, OH 44325, United States; Department of Biology, University of Akron, Akron, OH 44325, United States.
Sailaja ParuchuriDepartment of Chemistry, University of Akron, Akron, OH 44325, United States.
David A HunstadDepartments of Pediatrics and Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, United States.
Matthew J PanznerDepartment of Chemistry, University of Akron, Akron, OH 44325, United States.
Wiley J YoungsDepartment of Chemistry, University of Akron, Akron, OH 44325, United States. Electronic address: youngs@uakron.edu.
University of Akron · USWashington University in St. Louis · US

Funding

ADHESIN-BASED NANOTHERAPEUTICS IN URINARY TRACT INFECTIONR01DK082546 · NIDDK · WASHINGTON UNIVERSITY · PI HUNSTAD, DAVID · 2010 to 2014
$1.6M
NIDDK NIH HHS R01 DK082546
6 · The paper itself

Abstract

Alkyl- and N,N'-bisnaphthyl-substituted imidazolium salts were tested in vitro for their anti-cancer activity against four non-small cell lung cancer cell lines (NCI-H460, NCI-H1975, HCC827, A549). All compounds had potent anticancer activity with 2 having IC

Indexed as

A549 CellsAnimalsAntineoplastic AgentsBenzimidazolesCarbocyaninesCarcinoma, Non-Small-Cell LungCell Line, TumorCell SurvivalDrug Screening Assays, AntitumorHumansImidazolesKaplan-Meier EstimateLung NeoplasmsMembrane Potential, MitochondrialMiceMice, Inbred C57BL5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolocarbocyanineAntineoplastic AgentsBenzimidazolesCarbocyaninesImidazolesNaphtholsSaltsAnti-cancerAnti-tumorCyclodextrinImidazolium saltLung cancer

Identifiers

PMID28126518
PMCPMC5575737
OpenAlexW2578134235

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.