Evidence map›Paper›PMID 28126238›Full record

ArticleAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2017

Measures of Kidney Disease and the Risk of Venous Thromboembolism in the REGARDS (Reasons for Geographic and Racial Differences in Stroke) Study.

Katharine L Cheung, Neil A Zakai, Aaron R Folsom, Manjula Kurella Tamura, Carmen A Peralta, Suzanne E Judd, Peter W Callas, Mary Cushman

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Pooled it
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  7. Renal transplant and hemostasis: early postoperative changes in recipients and donors.Research and practice in thrombosis and haemostasis · 2023
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  18. Venous Thromboembolism Prophylaxis and Risk for Acutely Medically Ill Patients Stratified by Different Ages and Renal Disease Status.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Katharine L CheungLarner College of Medicine, University of Vermont, Burlington, VT. Electronic address: klcheung@med.uvm.edu.
Neil A ZakaiLarner College of Medicine, University of Vermont, Burlington, VT.
Aaron R FolsomUniversity of Minnesota, Minneapolis, MN.
Manjula Kurella TamuraGeriatrics Research Education and Clinical Center, Stanford University and VA Palo Alto Health Care System, Palo Alto, CA.
Carmen A PeraltaUniversity of California San Francisco, San Francisco, CA.
Suzanne E JuddUniversity of Alabama-Birmingham, Birmingham, AL.
Peter W CallasUniversity of Vermont, Burlington, VT.
Mary CushmanLarner College of Medicine, University of Vermont, Burlington, VT.

Funding

VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0M
Reasons for Racial Disparities in Venous ThromboembolismRC1HL099460 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI ZAKAI, NEIL ADRIAN · 2009 to 2010
$996k
NHLBI NIH HHS RC1 HL099460NINDS NIH HHS U01 NS041588
6 · The paper itself

Abstract

backgroundKidney disease has been associated with venous thromboembolism (VTE) risk, but results conflict and there is little information regarding blacks. STUDY

designProspective cohort study. SETTING &

participants30,239 black and white adults 45 years or older enrolled in the REGARDS (Reasons for Geographic and Racial Differences in Stroke) Study 2003 to 2007. PREDICTORS: Estimated glomerular filtration rate (eGFR) using the combined creatinine-cystatin C (eGFR OUTCOMES: The primary outcome was adjudicated VTE, and secondary outcomes were provoked and unprovoked VTE, separately. Mortality was a competing-risk event.

resultsDuring 4.6 years of follow-up, 239 incident VTE events occurred over 124,624 person-years. Cause-specific HRs of VTE were calculated using proportional hazards regression adjusted for age, sex, race, region of residence, and body mass index. Adjusted VTE HRs for eGFR LIMITATIONS: Single measurement of eGFR and ACR may have led to misclassification. Smaller numbers of events may have limited power.

conclusionsThere was an independent association of low eGFR (<45 vs ≥90mL/min/1.73m

Indexed as

Black or African AmericanWhite PeopleAgedAge FactorsFemaleHumansMaleMiddle AgedObesityProspective StudiesRenal Insufficiency, ChronicRisk AssessmentStrokeUnited StatesVenous Thromboembolismalbumin-creatinine ratio (ACR)albuminuriaChronic kidney disease (CKD)deep vein thrombosis and pulmonary embolusglomerular filtration rate (GFR)kidney disease measuresracerenal insufficiencyvascular diseasevenous thromboembolism (VTE)

Identifiers

PMID28126238
PMCPMC5522772

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.