Evidence map›Paper›PMID 28126025›Full record

ArticleJournal of cardiothoracic surgery2017

Anti-inflammatory properties of amniotic membrane patch following pericardiectomy for constrictive pericarditis.

Katherine M Marsh, Alice S Ferng, Tia Pilikian, Ankit A Desai, Ryan Avery, Mark Friedman, Isabel Oliva, Clint Jokerst, David Schipper, Zain Khalpey

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiothoracic surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

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  15. Amniotic membrane as novel scaffold for human iPSC-derived cardiomyogenesis.In vitro cellular & developmental biology. Animal · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Katherine M MarshDepartment of Surgery, Division of Cardiothoracic Surgery, University of Arizona College of Medicine, 1501 North Campbell Avenue, Room 4302, Tucson, AZ, 85724, USA.
Alice S FerngDepartment of Surgery, Division of Cardiothoracic Surgery, University of Arizona College of Medicine, 1501 North Campbell Avenue, Room 4302, Tucson, AZ, 85724, USA.
Tia PilikianDepartment of Surgery, Division of Cardiothoracic Surgery, University of Arizona College of Medicine, 1501 North Campbell Avenue, Room 4302, Tucson, AZ, 85724, USA.
Ankit A DesaiDepartment of Internal Medicine, Division of Cardiology, University of Arizona College of Medicine, Tucson, USA.
Ryan AveryDepartment of Medical Imaging, University of Arizona College of Medicine, Tucson, USA.
Mark FriedmanDepartment of Internal Medicine, Division of Cardiology, University of Arizona College of Medicine, Tucson, USA.
Isabel OlivaDepartment of Medical Imaging, University of Arizona College of Medicine, Tucson, USA.
Clint JokerstDepartment of Medical Imaging, University of Arizona College of Medicine, Tucson, USA.
David SchipperDepartment of Surgery, Division of Cardiothoracic Surgery, University of Arizona College of Medicine, 1501 North Campbell Avenue, Room 4302, Tucson, AZ, 85724, USA.
Zain KhalpeyDepartment of Surgery, Division of Cardiothoracic Surgery, University of Arizona College of Medicine, 1501 North Campbell Avenue, Room 4302, Tucson, AZ, 85724, USA. zkhalpey@surgery.arizona.edu.
University of Arizona · US

Funding

Pathogenic Role of IL-18 in Sickle Cell Cardiomyopathy and Inducible Ventricular TachycardiaR01HL136603 · NHLBI · UNIVERSITY OF ARIZONA · PI DESAI, ANKIT A · 2017 to 2021
$2.4M
NHLBI NIH HHS R01 HL136603
6 · The paper itself

Abstract

backgroundSince constrictive pericarditis is most often idiopathic and the pathophysiology remains largely unknown, both the diagnosis and the treatment can be challenging. However, by definition, inflammatory processes are central to this disease process. Amniotic membrane patches have been shown to possess anti-inflammatory properties and are believed to be immune privileged. Due to these properties, amniotic membrane patches were applied intraoperatively in a complicated patient presenting with constrictive pericarditis. CASE PRESENTATION: A patient with a history of multiple cardiac surgeries presented with marked fatigue, worsening dyspnea and sinus tachycardia. He was found to have constrictive physiology during cardiac catheterization, with cardiac MRI demonstrating hepatic vein dilatation, atrial enlargement and ventricular narrowing. After amniotic membrane patch treatment and pericardiectomy, post-operative cardiac MRI failed to demonstrate any appreciable pericardial effusion or inflammation, with no increased T2 signal that would suggest edema.

conclusionsGiven the positive results seen in this complex patient, we suggest continued research into the beneficial properties of amniotic membrane patches in cardiac surgery.

Indexed as

PericardiectomyAdultAmnionHumansInflammationMagnetic Resonance ImagingMalePericardial EffusionPericarditis, ConstrictiveAmniotic membrane patchConstrictive pericarditisOrthotopic heart transplant

Identifiers

PMID28126025
PMCPMC5270242
OpenAlexW2579980522

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.