ArticleBMC psychiatry2017
The Youth Mental Health Risk and Resilience Study (YouR-Study).
Article in BMC psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Psychosis-like experiences and resilience: A systematic and critical review of the literature.Psychological services · 2022Pooled it
- Large-scale maps of altered cortical dynamics in early-stage psychosis are related to GABAergic and glutamatergic neurotransmission.Science advances · 2025Article
- Clinical prediction model for transition to psychosis in individuals meeting At Risk Mental State criteria.Schizophrenia (Heidelberg, Germany) · 2025Article
- Clinical and Functional Outcomes of Community-Recruited Individuals at Clinical High-Risk for Psychosis: Results From the Youth Mental Health Risk and Resilience Study (YouR-Study).Schizophrenia bulletin open · 2024Article
- Thalamo-cortical circuits during sensory attenuation in emerging psychosis: a combined magnetoencephalography and dynamic causal modelling study.Schizophrenia (Heidelberg, Germany) · 2023Article
- Ethnoracial discrimination and the development of suspiciousness symptoms in individuals at clinical high-risk for psychosis.Schizophrenia research · 2023Article
- Investigating temporal and prosodic markers in clinical high-risk for psychosis participants using automated acoustic analysis.Early intervention in psychiatry · 2023Article
- Characterising cognitive heterogeneity in individuals at clinical high-risk for psychosis: a cluster analysis with clinical and functional outcome prediction.European archives of psychiatry and clinical neuroscience · 2022Article
- MR-Spectroscopy of GABA and Glutamate/Glutamine Concentrations in Auditory Cortex in Clinical High-Risk for Psychosis Individuals.Frontiers in psychiatry · 2022Article
- Hippocampal structural alterations in early-stage psychosis: Specificity and relationship to clinical outcomes.NeuroImage. Clinical · 2022Article
- Prevalence and predictors of suicidality and non-suicidal self-harm among individuals at clinical high-risk for psychosis: Results from a community-recruited sample.Early intervention in psychiatry · 2021Article
- Duration of basic and attenuated-psychotic symptoms in individuals at clinical high risk for psychosis: pattern of symptom onset and effects of duration on functioning and cognition.BMC psychiatry · 2021Article
- Long range temporal correlations (LRTCs) in MEG-data during emerging psychosis: Relationship to symptoms, medication-status and clinical trajectory.NeuroImage. Clinical · 2021Article
- Grey-matter abnormalities in clinical high-risk participants for psychosis.Schizophrenia research · 2020Article
- Association of Magnetoencephalographically Measured High-Frequency Oscillations in Visual Cortex With Circuit Dysfunctions in Local and Large-scale Networks During Emerging Psychosis.JAMA psychiatry · 2020Article
- Altered Autonomic Function in Individuals at Clinical High Risk for Psychosis.Frontiers in psychiatry · 2020Article
- Neuropsychological deficits in participants at clinical high risk for psychosis recruited from the community: relationships to functioning and clinical symptoms.Psychological medicine · 2020Article
- Using Online Screening in the General Population to Detect Participants at Clinical High-Risk for Psychosis.Schizophrenia bulletin · 2019Article
- Improving the Detection of Individuals at Clinical Risk for Psychosis in the Community, Primary and Secondary Care: An Integrated Evidence-Based Approach.Frontiers in psychiatry · 2019Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe transition from adolescence to adulthood is associated with the emergence of psychosis and other mental health problems, highlighting the importance of this developmental period for the understanding of developing psychopathology and individual differences in risk and resilience. The Youth Mental Health Risk and Resilience Study (YouR-Study) aims to identify neurobiological mechanisms and predictors of psychosis-risk with a state-of-the-art neuroimaging approach (Magnetoencephalography, Magnetic Resonance Spectroscopy, Magnetic Resonance Imaging) in combination with core psychological processes, such as affect regulation and attachment, that have been implicated in the development and maintenance of severe mental health problems. METHODS/
designOne hundred participants meeting clinical high-risk criteria (CHR) for psychosis through the Comprehensive Assessment of At-Risk Mental State and Schizophrenia Proneness Instrument, Adult Version, in the age range from 16 to 35 years of age will be recruited. Mental-state monitoring up to a total of 2 years will be implemented to detect transition to psychosis. In addition, a sample of n = 40 help-seeking participants will be recruited who do not meet CHR-criteria, a group of n = 50 healthy control participants and a sample of n = 25 patients with first-episode psychosis. MEG-activity will be obtained during auditory and visual tasks to examine neural oscillations and event-related fields. In addition, we will obtain estimates of GABA and Glutamate levels through Magnetic Resonance Spectroscopy (MRS) to examine relationships between neural synchrony and excitatory-inhibition (E/I) balance parameters. Neuroimaging will be complemented by detailed neuropsychological assessments as well as psychological measures investigating the impact of childhood abuse, attachment experiences and affect regulation. DISCUSSION: The YouR-study could potentially provide important insights into the neurobiological mechanisms that confer risk for psychosis as well as biomarkers for early diagnosis of severe mental health problems. Moreover, we expect novel data related to the contribution of affect regulation and attachment-processes in the development of mental health problems, leading to an integrative model of early stage psychosis and the factors underlying risk and resilience of emerging psychopathology.
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