Evidence map›Paper›PMID 28125977›Full record

Trial reportBMC geriatrics2017

Supporting clinical rules engine in the adjustment of medication (SCREAM): protocol of a multicentre, prospective, randomised study.

Carlota Mestres Gonzalvo, Hugo A J M de Wit, Brigit P C van Oijen, Kim P G M Hurkens, Rob Janknegt, Jos M G A Schols, Wubbo J Mulder, Frans R Verhey, Bjorn Winkens, Paul-Hugo M van der Kuy

Abstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in BMC geriatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Review
  7. Article
  8. [Interventions to optimise prescribing for older people in care homes].Zeitschrift fur Gerontologie und Geriatrie · 2020
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Carlota Mestres GonzalvoDepartment of Clinical Pharmacy and Toxicology, Zuyderland Medical Centre, Sittard, The Netherlands. c.mestresgonzalvo@zuyderland.nl.
Hugo A J M de WitDepartment of Clinical Pharmacy and Toxicology, Zuyderland Medical Centre, Heerlen, The Netherlands.
Brigit P C van OijenDepartment of Clinical Pharmacy and Toxicology, Zuyderland Medical Centre, Sittard, The Netherlands.
Kim P G M HurkensDepartment of Internal Medicine, Zuyderland Medical Centre, Heerlen, The Netherlands.
Rob JanknegtDepartment of Clinical Pharmacy and Toxicology, Zuyderland Medical Centre, Sittard, The Netherlands.
Jos M G A ScholsDepartment of Family Medicine and Department of Health Services Research, School for Public Health and Primary Care (CAPHRI), Maastricht University, Maastricht, The Netherlands.
Wubbo J MulderDepartment of Internal Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands.
Frans R VerheyDepartment of Psychiatry and Neuropsychology, Alzheimer Centre Limburg/School for Mental Health and Neurosciences (MHeNS), Maastricht University, Maastricht, The Netherlands.
Bjorn WinkensDepartment of Methodology and Statistics, School for Public Health and Primary Care (CAPHRI), Maastricht University, Maastricht, The Netherlands.
Paul-Hugo M van der KuyDepartment of Clinical Pharmacy and Toxicology, Zuyderland Medical Centre, Sittard, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn the nursing home population, it is estimated that 1 in every 3 patients is polymedicated and given their considerable frailty, these patients are especially prone to adverse drug reactions. Clinical pharmacist-led medication reviews are considered successful interventions to improve medication safety in the inpatient setting. Due to the limited available evidence concerning the benefits of medication reviews performed in the nursing home setting, we propose a study aiming to demonstrate a positive effect that a clinical decision support system, as a health care intervention, may have on the target population. The primary objective of this study is to reduce the number of patients with at least one event when using the clinical decision support system compared to the regular care. These events consist of hospital referrals, delirium, falls, and/or deaths. METHOD/

designThis study is a multicentre, prospective, randomised study with a cluster group design. The randomisation will be per main nursing home physician and stratified per ward (somatic and psychogeriatric). In the intervention group the clinical decision support system will be used to screen medication list, laboratory values and medical history in order to obtain potential clinical relevant remarks. The remarks will be sent to the main physician and feedback will be provided whether the advice was followed or not. In the control group regular care will be applied. DISCUSSION: We strongly believe that by using a clinical decision support system, medication reviews are performed in a standardised way which leads to comparable results between patients. In addition, using a clinical decision support system eliminates the time factor to perform medication reviews as the major problems related to medication, laboratory values, indications and/or established patient characteristics will be directly available. In this way, and in order to make the medication review process complete, consultation within healthcare professionals and/or the patient itself will be time effective and the medication surveillance could be performed around the clock.

trial registrationThe Netherlands National Trial Register NTR5165 . Registered 2nd April 2015.

Indexed as

Accidental FallsAgedDecision Support Systems, ClinicalDeliriumDrug-Related Side Effects and Adverse ReactionsFemaleHomes for the AgedHumansMaleMedication Therapy ManagementNetherlandsNursing HomesPolypharmacyProspective StudiesQuality ImprovementReferral and ConsultationAgedDecision support systems managementMedication reviewMedication therapy managementPolypharmacy

Identifiers

PMID28125977
PMCPMC5270253

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.