ArticleBritish journal of cancer2017
Composite protective lifestyle factors and risk of developing gastric adenocarcinoma: the Singapore Chinese Health Study.
Article in British journal of cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Diet and Risk of Gastric Cancer: An Umbrella Review.Nutrients · 2022Pooled it
- Body Mass Index and Risk of Gastric Cancer in Asian Adults: A Meta-Epidemiological Meta-Analysis of Population-Based Cohort Studies.Cancer research and treatment · 2020Pooled it
- Alcohol intake and risk of stomach cancer: a pooled analysis of 20 cohorts.JNCI cancer spectrum · 2026Article
- Article
- Determinants ofBMJ open · 2026Article
- High expression of GRB14 is associated with cancer progression and poor prognosis in gastric cancer.Discover oncology · 2025Article
- Uncovering a New Concept of Foodnality in Diet Recommendations for Chinese Aging Populations Based on Systematic and Bibliometric Review.Foods (Basel, Switzerland) · 2024Review
- Public awareness of gastric cancer risk factors and screening behaviours in Shijiazhuang, China: A community-based survey.PloS one · 2024Article
- Cluster of lifestyle risk factors for stomach cancer and screening behaviors among Korean adults.Scientific reports · 2023Article
- The impact of a healthy lifestyle on the risk of esophageal and gastric cancer subtypes.European journal of epidemiology · 2022Article
- The mediating role of combined lifestyle factors on the relationship between education and gastric cancer in the Stomach cancer Pooling (StoP) Project.British journal of cancer · 2022Article
- Dietary Reference Intakes of sodium for Koreans: focusing on a new DRI component for chronic disease risk reduction.Nutrition research and practice · 2022Review
- Composite Score of Healthy Lifestyle Factors and the Risk of Pancreatic Cancer in a Prospective Cohort Study.Cancer prevention research (Philadelphia, Pa.) · 2022Article
- Decreased expression of ATF3, orchestrated by β-catenin/TCF3, miR-17-5p and HOXA11-AS, promoted gastric cancer progression via increased β-catenin and CEMIP.Experimental & molecular medicine · 2021Article
- Sociodemographic disparity in health-related behaviours and dietary habits among public workers in China: a cross-sectional study.BMJ open · 2021Article
- Sex as an effect modifier in the association between alcohol intake and gastric cancer risk.World journal of gastrointestinal oncology · 2021Article
- Composite Score of Healthy Lifestyle Factors and Risk of Hepatocellular Carcinoma: Findings from a Prospective Cohort Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021Article
- Article
- Healthy Lifestyle Factors, Cancer Family History, and Gastric Cancer Risk: A Population-Based Case-Control Study in China.Frontiers in nutrition · 2021Article
- Dietary Salt Intake and Gastric Cancer Risk: A Systematic Review and Meta-Analysis.Frontiers in nutrition · 2021Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundIncidence of gastric cancer is the highest in Eastern Asia. Multiple modifiable lifestyle factors have been identified as risk factors for gastric cancer. However, their aggregated effect on the risk of gastric cancer has not been examined among populations with high prevalence of Helicobacter pylori.
methodsA study was conducted to examine the association between multiple lifestyle factors together and the risk of developing gastric adenocarcinoma in the Singapore Chinese Health Study, a prospective cohort of 63 257 men and women between 45 and 74 years enroled during 1993-1998. Composite score of cigarette smoking, alcohol consumption, obesity, dietary pattern, and sodium intake at baseline was assessed with hazard ratio (HR) and 95% confidence interval (CI) of gastric adenocarcinoma using Cox regression method.
resultsHigher healthy composite lifestyle scores were significantly associated with reduced risk of gastric adenocarcinoma in a dose-dependent manner. Hazard ratios (95% CIs) for total, cardia, and non-cardia gastric adenocarcinoma for the highest (score 5) vs lowest composite score (score 0/1/2) were 0.42 (0.31-0.57), 0.22 (0.10-0.47), and 0.55 (0.39-0.78), respectively (all P
conclusionsThe inverse association between the aggregated healthy lifestyle factors and the risk of gastric adenocarcinoma is in dose-dependent manner in this highly H. pylori-exposed population. These lifestyle factors together may account for up to half of disease burden in this study population.
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