Evidence map›Paper›PMID 28125789›Full record

ArticleCell systems2017

Codon Clarity or Conundrum?

Daniel P Aalberts, Gregory Boël, John F Hunt

Open access · bronzeAbstract readComment
In one paragraph

Article in Cell systems, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Daniel P AalbertsPhysics Department, Williams College, Williamstown, MA 01267, USA. Electronic address: aalberts@williams.edu.
Gregory BoëlInstitut de Biologie Physico-Chemique, CNRS, 75005 Paris, France. Electronic address: boel@ibpc.fr.
John F HuntDepartment of Biological Sciences, Columbia University, New York, NY 10024, USA. Electronic address: jfh21@columbia.edu.
Columbia University · USInstitut de Biologie Physico-Chimique · FRWilliams College · US

Funding

University of Georgia ProjectU54GM094597 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI ROST, BURKHARD · 2010 to 2014
$36.9M
Sub 9 at AECMU54GM075026 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI INOUYE, MASAYORI · 2005 to 2009
$16.8M
Biophysical mechanisms of ABC-F proteinsR01GM120579 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI HUNT, JOHN FRANCIS · 2016 to 2019
$1.3M
AREA: Optimizing gene expression with mRNA free energy modeling and algorithmsR15GM106372 · NIGMS · WILLIAMS COLLEGE · PI AALBERTS, DANIEL PAUL · 2014 to 2014
$255k
NIGMS NIH HHS R01 GM120579NIGMS NIH HHS R15 GM106372NIGMS NIH HHS U54 GM075026NIGMS NIH HHS U54 GM094597
6 · The paper itself

Abstract

Synonymous variations in protein-coding sequences alter protein expression dynamics, which has important implications for cellular physiology and evolutionary fitness, but disentangling the underlying molecular mechanisms remains challenging.

Indexed as

Biological EvolutionCodonGene ExpressionOpen Reading FramesCodon

Identifiers

PMID28125789
PMCPMC5318996
OpenAlexW2579979975

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.