ArticlePloS one2017
Identification of Structural Features of Condensed Tannins That Affect Protein Aggregation.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 63 citations in OpenAlex.
- Polymerization degree-driven impact on digestive enzyme inhibition by proanthocyanidins: mechanistic insights.Food chemistry: X · 2026Article
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- L-Proline-Mediated Modulation of Astringency in Black Chokeberry Puree: Molecular Interactions, Process Optimization, and Quality Preservation.Foods (Basel, Switzerland) · 2026Article
- Effect of Water Level and Tannin Inclusion on In Vitro Degradability and Digestibility of Soybean Meal.Animals : an open access journal from MDPI · 2026Article
- Exploring the Interactions between Plant Proanthocyanidins and Thiabendazole: Insights from Isothermal Titration Calorimetry.Molecules (Basel, Switzerland) · 2024Article
- Effects of Increasing Levels of Total Tannins on Intake, Digestibility, and Balance of Nitrogen, Water, and Energy in Hair Lambs.Animals : an open access journal from MDPI · 2023Article
- The study of structure and effects of two new proanthocyanidins fromFrontiers in veterinary science · 2023Article
- Biophysical Approaches for the Characterization of Protein-Metabolite Interactions.Methods in molecular biology (Clifton, N.J.) · 2023Review
- Tannin in Ruminant Nutrition: Review.Molecules (Basel, Switzerland) · 2022Review
- Influence of the Hydrolyzable Tannin Structure on the Characteristics of Insoluble Hydrolyzable Tannin-Protein Complexes.Journal of agricultural and food chemistry · 2022Article
- Azolla ferns testify: seed plants and ferns share a common ancestor for leucoanthocyanidin reductase enzymes.The New phytologist · 2021Article
- Composition and Protein Precipitation Capacity of Condensed Tannins in Purple Prairie Clover (Frontiers in plant science · 2021Article
- Condensed Tannins in White Clover (Frontiers in plant science · 2021Article
- Changes in Feed Proanthocyanidin Profiles during Silage Production and Digestion by Lamb.Molecules (Basel, Switzerland) · 2020Article
- Distribution of Protein Precipitation Capacity within Variable Proanthocyanidin Fingerprints.Molecules (Basel, Switzerland) · 2020Article
- Article
- Elucidation of the Interaction between Flavan-3-ols and Bovine Serum Albumin and Its Effect on Their In-Vitro Cytotoxicity.Molecules (Basel, Switzerland) · 2019Article
- Influence of Calcium Ions on the Thermal Characteristics of α-amylase from Thermophilic Anoxybacillus sp. GXS-BL.Protein and peptide letters · 2019Article
- Characterization of Condensed Tannins from Purple Prairie Clover (Dalea purpurea Vent.) Conserved as either Freeze-Dried Forage, Sun-Cured Hay or Silage.Molecules (Basel, Switzerland) · 2018Article
- The Rhizobia-Frontiers in microbiology · 2018Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A diverse panel of condensed tannins was used to resolve the confounding effects of size and subunit composition seen previously in tannin-protein interactions. Turbidimetry revealed that size in terms of mean degree of polymerisation (mDP) or average molecular weight (amw) was the most important tannin parameter. The smallest tannin with the relatively largest effect on protein aggregation had an mDP of ~7. The average size was significantly correlated with aggregation of bovine serum albumin, BSA (mDP: r = -0.916; amw: r = -0.925; p<0.01; df = 27), and gelatin (mDP: r = -0.961; amw: r = -0.981; p<0.01; df = 12). The procyanidin/prodelphinidin and cis-/trans-flavan-3-ol ratios gave no significant correlations. Tryptophan fluorescence quenching indicated that procyanidins and cis-flavan-3-ol units contributed most to the tannin interactions on the BSA surface and in the hydrophobic binding pocket (r = 0.677; p<0.05; df = 9 and r = 0.887; p<0.01; df = 9, respectively). Circular dichroism revealed that higher proportions of prodelphinidins decreased the apparent α-helix content (r = -0.941; p<0.01; df = 5) and increased the apparent β-sheet content (r = 0.916; p<0.05; df = 5) of BSA.
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