Evidence map›Paper›PMID 28125601›Full record

SynthesisPloS one2017

Effects of Coenzyme Q10 on Markers of Inflammation: A Systematic Review and Meta-Analysis.

Junya Zhai, Yacong Bo, Yan Lu, Chunli Liu, Lishi Zhang

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 7 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 7 syntheses or guidelines pooled it, 127 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Coenzyme QNutrients · 2022
    Pooled it
  5. Pooled it
  6. Coenzyme QInternational journal of molecular sciences · 2020
    Pooled it
  7. Pooled it
  8. Review
  9. Nutraceutical Effects ofNutrients · 2026
    Article
  10. Article
  11. Article
  12. Review
  13. A Pilot Trial of Nicotinamide Riboside and Coenzyme Q10 on Inflammation and Oxidative Stress in CKD.Clinical journal of the American Society of Nephrology : CJASN · 2025
    Article
  14. Article
  15. Review
  16. Article
  17. The Scavenging Activity of Coenzyme QInternational journal of molecular sciences · 2024
    Article
  18. Article
  19. Article
  20. Review

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Junya ZhaiDepartment of Nutrition, Food Safety and Toxicology, West China School of Public Health, Sichuan University. Chengdu, China.
Yacong BoDepartment of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.
Yan LuDepartment of Surgery, Shanghai Ninth People's Hospital (North), Shanghai Jiaotong University School of Medicine, Shanghai, China.
Chunli LiuThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Lishi ZhangDepartment of Nutrition, Food Safety and Toxicology, West China School of Public Health, Sichuan University. Chengdu, China.
Sichuan University · CNFirst Affiliated Hospital of Zhengzhou University · CNShanghai Ninth People's Hospital · CNZhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectiveChronic inflammation contributes to the onset and development of metabolic diseases. Clinical evidence has suggested that coenzyme Q10 (CoQ10) has some effects on inflammatory markers. However, these results are equivocal. The aim of this systematic review was to assess the effects of CoQ10 on serum levels of inflammatory markers in people with metabolic diseases.

methodsElectronic databases were searched up to February 2016 for randomized controlled trials (RCTs). The outcome parameters were related to inflammatory factors, including interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α) and C reactive protein (CRP). RevMan software was used for meta-analysis. Meta-regression analysis, Egger line regression test and Begg rank correlation test were performed by STATA software.

resultsNine trials involving 428 subjects were included in this meta-analysis. The results showed that compared with control group, CoQ10 supplementation has significantly improved the serum level of CoQ10 by 1.17μg/ml [MD = 1.17, 95% CI (0.47 to 1.87) μg/ml, I2 = 94%]. Meanwhile, it has significantly decreased TNF-α by 0.45 pg/ml [MD = -0.45, 95% CI (-0.67 to -0.24) pg/ml, I2 = 0%]. No significant difference was observed between CoQ10 and placebo with regard to CRP [MD = -0.21, 95% CI (-0.60 to 0.17) mg/L, I2 = 21%] and IL-6 [MD = -0.89, 95% CI (-1.95 to 0.16) pg/ml, I2 = 84%].

conclusionsCoQ10 supplementation may partly improve the process of inflammatory state. The effects of CoQ10 on inflammation should be further investigated by conducting larger sample size and well-defined trials of long enough duration.

Indexed as

BiomarkersC-Reactive ProteinDietary SupplementsElectronic Health RecordsHumansInflammationInterleukin-6Randomized Controlled Trials as TopicTumor Necrosis Factor-alphaUbiquinoneBiomarkerscoenzyme Q10C-Reactive ProteinIL6 protein, humanInterleukin-6Tumor Necrosis Factor-alphaUbiquinone

Identifiers

PMID28125601
PMCPMC5268485
OpenAlexW2582349744

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.