Evidence map›Paper›PMID 28125387›Full record

ReviewAnnual review of public health2017

Toward Greater Implementation of the Exposome Research Paradigm within Environmental Epidemiology.

Jeanette A Stingone, Germaine M Buck Louis, Shoji F Nakayama, Roel C H Vermeulen, Richard K Kwok, Yuxia Cui, David M Balshaw, Susan L Teitelbaum

Abstract readReview
In one paragraph

Review in Annual review of public health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Sharing common measures of the environment across continents: challenges and opportunities for global studies of aging.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Geospatial Science for the Environmental Epidemiology of Cancer in the Exposome Era.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jeanette A StingoneDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029; email: jeanette.stingone@mssm.edu , susan.teitelbaum@mssm.edu.
Germaine M Buck LouisDivision of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland 20817; email: louisg@mail.nih.gov.
Shoji F NakayamaNational Institute for Environmental Studies, Tsukuba 305-0053, Japan; email: fabre@nies.go.jp.
Roel C H VermeulenInstitute for Risk Assessment Sciences, Environmental Epidemiology Division, Utrecht University, Utrecht 3584 CM, Netherlands; email: R.C.H.Vermeulen@uu.nl.
Richard K KwokEpidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; email: richard.kwok@nih.gov.
Yuxia CuiExposure, Response, and Technology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; email: yuxia.cui@nih.gov , balshaw@niehs.nih.gov.
David M BalshawExposure, Response, and Technology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; email: yuxia.cui@nih.gov , balshaw@niehs.nih.gov.
Susan L TeitelbaumDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029; email: jeanette.stingone@mssm.edu , susan.teitelbaum@mssm.edu.

Funding

Statistical Services and Methods Development ResourceU2CES026555 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GENNINGS, CHRIS · 2015 to 2025
$26.4M
The Mount Sinai Transdisciplinary Center on Early Environmental ExposuresP30ES023515 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Robert O Wright · 2014 to 2026
$21.3M
NIEHS NIH HHS P30 ES023515NIEHS NIH HHS U2C ES026555
6 · The paper itself

Abstract

Investigating a single environmental exposure in isolation does not reflect the actual human exposure circumstance nor does it capture the multifactorial etiology of health and disease. The exposome, defined as the totality of environmental exposures from conception onward, may advance our understanding of environmental contributors to disease by more fully assessing the multitude of human exposures across the life course. Implementation into studies of human health has been limited, in part owing to theoretical and practical challenges including a lack of infrastructure to support comprehensive exposure assessment, difficulty in differentiating physiologic variation from environmentally induced changes, and the need for study designs and analytic methods that accommodate specific aspects of the exposome, such as high-dimensional exposure data and multiple windows of susceptibility. Recommendations for greater data sharing and coordination, methods development, and acknowledgment and minimization of multiple types of measurement error are offered to encourage researchers to embark on exposome research to promote the environmental health and well-being of all populations.

Indexed as

Environmental HealthEnvironmentEnvironmental ExposureHumansResearch Designenvironmental epidemiologyexposomelife-course epidemiologymultiple exposures

Identifiers

PMID28125387
PMCPMC5664945

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.