ArticleJournal of biomaterials science. Polymer edition2017
Extrusion-based 3D printing of poly(propylene fumarate) scaffolds with hydroxyapatite gradients.
Article in Journal of biomaterials science. Polymer edition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Review
- Evaluation of the Morphological Effects of Hydroxyapatite Nanoparticles on the Rheological Properties and Printability of Hydroxyapatite/Polycaprolactone Nanocomposite Inks and Final Scaffold Features.3D printing and additive manufacturing · 2024Article
- Research and application of polypropylene: a review.Discover nano · 2024Review
- Therapeutic functions of medical implants from various material categories with integrated biomacromolecular systems.Frontiers in bioengineering and biotechnology · 2024Review
- Review
- Species-Based Differences in Mechanical Properties, Cytocompatibility, and Printability of Methacrylated Collagen Hydrogels.Biomacromolecules · 2022Article
- Flow Simulation and Gradient Printing of Fluorapatite- and Cell-Loaded Recombinant Spider Silk Hydrogels.Biomolecules · 2022Article
- Hybprinting for musculoskeletal tissue engineering.iScience · 2022Review
- Design strategies for composite matrix and multifunctional polymeric scaffolds with enhanced bioactivity for bone tissue engineering.Frontiers in chemistry · 2022Review
- Additive Manufacturing: The Next Generation of Scapholunate Ligament Reconstruction.Journal of wrist surgery · 2021Article
- Biodegradable materials for bone defect repair.Military Medical Research · 2020Review
- Fiber engraving for bioink bioprinting within 3D printed tissue engineering scaffolds.Bioprinting (Amsterdam, Netherlands) · 2020Article
- Multimaterial Dual Gradient Three-Dimensional Printing for Osteogenic Differentiation and Spatial Segregation.Tissue engineering. Part A · 2020Article
- Aminated 3D Printed Polystyrene Maintains Stem Cell Proliferation and Osteogenic Differentiation.Tissue engineering. Part C, Methods · 2020Article
- Solvent-based Extrusion 3D Printing for the Fabrication of Tissue Engineering Scaffolds.International journal of bioprinting · 2020Review
- Engineered 3D Polymer and Hydrogel Microenvironments for Cell Culture Applications.Bioengineering (Basel, Switzerland) · 2019Review
- Controlled Preparation of Nanoparticle Gradient Materials by Diffusion.Nanomaterials (Basel, Switzerland) · 2019Article
- Three-Dimensional Printing of Tissue Engineering Scaffolds with Horizontal Pore and Composition Gradients.Tissue engineering. Part C, Methods · 2019Article
- Fabrication and mechanical characterization of 3D printed vertical uniform and gradient scaffolds for bone and osteochondral tissue engineering.Acta biomaterialia · 2019Article
- A comprehensive review of biodegradable synthetic polymer-ceramic composites and their manufacture for biomedical applications.Bioactive materials · 2019Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The primary focus of this work is to present the current challenges of printing scaffolds with concentration gradients of nanoparticles with an aim to improve the processing of these scaffolds. Furthermore, we address how print fidelity is related to material composition and emphasize the importance of considering this relationship when developing complex scaffolds for bone implants. The ability to create complex tissues is becoming increasingly relevant in the tissue engineering community. For bone tissue engineering applications, this work demonstrates the ability to use extrusion-based printing techniques to control the spatial deposition of hydroxyapatite (HA) nanoparticles in a 3D composite scaffold. In doing so, we combined the benefits of synthetic, degradable polymers, such as poly(propylene fumarate) (PPF), with osteoconductive HA nanoparticles that provide robust compressive mechanical properties. Furthermore, the final 3D printed scaffolds consisted of well-defined layers with interconnected pores, two critical features for a successful bone implant. To demonstrate a controlled gradient of HA, thermogravimetric analysis was carried out to quantify HA on a per-layer basis. Moreover, we non-destructively evaluated the tendency of HA particles to aggregate within PPF using micro-computed tomography (μCT). This work provides insight for proper fabrication and characterization of composite scaffolds containing particle gradients and has broad applicability for future efforts in fabricating complex scaffolds for tissue engineering applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.