Evidence map›Paper›PMID 28125329›Full record

ReviewSmall GTPases2018

Role of Rab GTPases in the export trafficking of G protein-coupled receptors.

Guansong Wang, Zhe Wei, Guangyu Wu

Open access · bronzeAbstract readReview
In one paragraph

Review in Small GTPases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. In vivo mapping of a GPCR interactome using knockin mice.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  6. Article
  7. Updates in the function and regulation of αBritish journal of pharmacology · 2019
    Review
  8. Review
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Guansong Wanga Institute of Respiratory Diseases, Xinqiao Hospital, Third Military Medical University , Chongqing , China.
Zhe Weib Department of Pharmacology and Toxicology , Medical College of Georgia, Augusta University , Augusta , GA , USA.
Guangyu Wub Department of Pharmacology and Toxicology , Medical College of Georgia, Augusta University , Augusta , GA , USA.
Augusta University · USXinqiao Hospital · CN

Funding

Anterograde transport and signal regulation of GPCRsR01GM118915 · NIGMS · AUGUSTA UNIVERSITY · PI WU, GUANGYU · 2016 to 2019
$1.3M
NIGMS NIH HHS R01 GM118915
6 · The paper itself

Abstract

G protein-coupled receptors (GPCRs) constitute a superfamily of cell surface receptors that regulate a variety of cell functions. As the cell surface is the functional destination for most GPCRs, the cell surface targeting process represents a crucial checkpoint in controlling the functionality of the receptors. However, the molecular mechanisms underlying the cell surface delivery of newly synthesized GPCRs remain poorly understood. In this review, we will highlight the role of Rab GTPases in GPCR cell surface transport, particularly post-Golgi traffic, and discuss the underlying molecular mechanisms.

Indexed as

AnimalsHumansProtein Transportrab GTP-Binding ProteinsReceptors, G-Protein-CoupledSubstrate Specificityrab GTP-Binding ProteinsReceptors, G-Protein-Coupledcell surface expressionexport traffickingG protein-coupled receptorpost-Golgi trafficRab26Rab8Rab GTPase

Identifiers

PMID28125329
PMCPMC5902197
OpenAlexW2581293500

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.