Evidence map›Paper›PMID 28125064›Full record

ArticleInternational journal of molecular sciences2017

Phenylarsine Oxide Can Induce the Arsenite-Resistance Mutant PML Protein Solubility Changes.

Yu Han Jiang, Ye Jia Chen, Chao Wang, Yong Fei Lan, Chang Yang, Qian Qian Wang, Liaqat Hussain, Yasen Maimaitiying, Khairul Islam, Hua Naranmandura

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Yu Han JiangDepartment of Toxicology, School of Medicine and Public health, Zhejiang University, Hangzhou 310058, China. 21434054@zju.edu.cn.
Ye Jia ChenDepartment of Toxicology, School of Medicine and Public health, Zhejiang University, Hangzhou 310058, China. cyjdota@163.com.
Chao WangDepartment of Toxicology, School of Medicine and Public health, Zhejiang University, Hangzhou 310058, China. 11618280@zju.edu.cn.
Yong Fei LanDepartment of Toxicology, School of Medicine and Public health, Zhejiang University, Hangzhou 310058, China. 21419019@zju.edu.cn.
Chang YangDepartment of Toxicology, School of Medicine and Public health, Zhejiang University, Hangzhou 310058, China. 11518283@zju.edu.cn.
Qian Qian WangDepartment of Toxicology, School of Medicine and Public health, Zhejiang University, Hangzhou 310058, China. 11319039@zju.edu.cn.
Liaqat HussainDepartment of Toxicology, School of Medicine and Public health, Zhejiang University, Hangzhou 310058, China. liaqathussain@zju.edu.cn.
Yasen MaimaitiyingDepartment of Toxicology, School of Medicine and Public health, Zhejiang University, Hangzhou 310058, China. yasinjan@zju.edu.cn.
Khairul IslamDepartment of Toxicology, School of Medicine and Public health, Zhejiang University, Hangzhou 310058, China. drkhairul16@gmail.com.
Hua NaranmanduraDepartment of Toxicology, School of Medicine and Public health, Zhejiang University, Hangzhou 310058, China. narenman@zju.edu.cn.
Zhejiang University · CNZhejiang Ocean University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Arsenic trioxide (As₂O₃) has recently become one of the most effective drugs for treatment of patient with acute promyelocytic leukemia (APL), and its molecular mechanism has also been largely investigated. However, it has been reported that As₂O₃ resistant patients are frequently found in relapsed APL after consolidation therapy, which is due to the point mutations in B-box type 2 motifs of

Indexed as

MutationArsenicalsArsenitesDrug Resistance, NeoplasmGene ExpressionHEK293 CellsHumansPromyelocytic Leukemia ProteinProtein Processing, Post-TranslationalProteolysisSolubilityArsenicalsArsenitesoxophenylarsinePromyelocytic Leukemia Proteinacute promyelocytic leukemiaarsenic trioxidearsenitedimethylarsinous acidmonomethylarsonous acidphenylarsine oxidetrivalent arsenicals

Identifiers

PMID28125064
PMCPMC5343784
OpenAlexW2580224574

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.