Evidence map›Paper›PMID 28125047›Full record

ArticleInternational journal of molecular sciences2017

Identifying the Long-Term Role of Inducible Nitric Oxide Synthase after Contusive Spinal Cord Injury Using a Transgenic Mouse Model.

Dominic M Maggio, Amanpreet Singh, J Bryan Iorgulescu, Drew H Bleicher, Mousumi Ghosh, Michael M Lopez, Luis M Tuesta, Govinder Flora, W Dalton Dietrich, Damien D Pearse

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Polymer-Based Scaffold Strategies for Spinal Cord Repair and Regeneration.Frontiers in bioengineering and biotechnology · 2020
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Dominic M MaggioThe Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL 33136, USA. dominic.maggio@nih.gov.
Amanpreet SinghThe Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL 33136, USA. amanpu@gmail.com.
J Bryan IorgulescuThe Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL 33136, USA. jbi2001@med.cornell.edu.
Drew H BleicherThe Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL 33136, USA. drew.bleicher@jhsmiami.org.
Mousumi GhoshThe Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL 33136, USA. mghosh@med.miami.edu.
Michael M LopezThe Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL 33136, USA. Michael.Lopez@mch.com.
Luis M TuestaThe Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL 33136, USA. luis_tuesta@hms.harvard.edu.
Govinder FloraThe Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL 33136, USA. gjsflora@gmail.com.
W Dalton DietrichThe Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL 33136, USA. ddietrich@miami.edu.
Damien D PearseThe Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL 33136, USA. DPearse@med.miami.edu.
University of Miami · USHarvard University · USNeurological Surgery · USUniversity of Virginia · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inducible nitric oxide synthase (iNOS) is a potent mediator of oxidative stress during neuroinflammation triggered by neurotrauma or neurodegeneration. We previously demonstrated that acute iNOS inhibition attenuated iNOS levels and promoted neuroprotection and functional recovery after spinal cord injury (SCI). The present study investigated the effects of chronic iNOS ablation after SCI using

Indexed as

AnimalsAxonsDisease Models, AnimalFemaleGray MatterIntermediate FilamentsMiceMice, KnockoutMice, TransgenicNitric OxideNitric Oxide Synthase Type IIOxidative StressPosterior Horn CellsRecovery of FunctionSpinal Cord InjuriesWhite MatterNitric OxideNitric Oxide Synthase Type IIangiogenesisaxonfunctioninducible nitric oxide synthaseknockoutneuroprotectionoxidative stress

Identifiers

PMID28125047
PMCPMC5343782
OpenAlexW2582506352

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.