Evidence map›Paper›PMID 28125024›Full record

ReviewCancers2017

Interstitial Photodynamic Therapy-A Focused Review.

Gal Shafirstein, David Bellnier, Emily Oakley, Sasheen Hamilton, Mary Potasek, Karl Beeson, Evgueni Parilov

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
15.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 182 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Pure Organic AIE Nanoscintillator for X-ray Mediated Type I and Type II Photodynamic Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Gal ShafirsteinPhotodynamic Therapy Center, Department of Cell Stress Biology, Roswell Park Cancer Institute (RPCI), Elm & Carlton Streets, Buffalo, NY 14263, USA. Gal.Shafirstein@RoswellPark.org.
David BellnierPhotodynamic Therapy Center, Department of Cell Stress Biology, Roswell Park Cancer Institute (RPCI), Elm & Carlton Streets, Buffalo, NY 14263, USA. David.Bellnier@RoswellPark.org.
Emily OakleyPhotodynamic Therapy Center, Department of Cell Stress Biology, Roswell Park Cancer Institute (RPCI), Elm & Carlton Streets, Buffalo, NY 14263, USA. Emily.Oakley@RoswellPark.org.
Sasheen HamiltonPhotodynamic Therapy Center, Department of Cell Stress Biology, Roswell Park Cancer Institute (RPCI), Elm & Carlton Streets, Buffalo, NY 14263, USA. Sasheen.Hamilton@RoswellPark.org.
Mary PotasekSimphotek, Inc., 211 Warren St, Newark, NJ 07103, USA. mpotasek@simphotek.com.
Karl BeesonSimphotek, Inc., 211 Warren St, Newark, NJ 07103, USA. beesonk@simphotek.com.
Evgueni ParilovSimphotek, Inc., 211 Warren St, Newark, NJ 07103, USA. evp@simphotek.com.
Roswell Park Comprehensive Cancer Center · USSimphotek (United States) · US

Funding

StatisticsP01CA055791 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI GOLLNICK, SANDRA O. · 1992 to 2019
$36.0M
Integrated Image-guided Dosimetry & Treatment Planning PDTR01CA193610 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI SHAFIRSTEIN, GAL · 2016 to 2020
$2.5M
NCI NIH HHS P01 CA055791NCI NIH HHS R01 CA193610
6 · The paper itself

Abstract

Multiple clinical studies have shown that interstitial photodynamic therapy (I-PDT) is a promising modality in the treatment of locally-advanced cancerous tumors. However, the utilization of I-PDT has been limited to several centers. The objective of this focused review is to highlight the different approaches employed to administer I-PDT with photosensitizers that are either approved or in clinical studies for the treatment of prostate cancer, pancreatic cancer, head and neck cancer, and brain cancer. Our review suggests that I-PDT is a promising treatment in patients with large-volume or thick tumors. Image-based treatment planning and real-time dosimetry are required to optimize and further advance the utilization of I-PDT. In addition, pre- and post-imaging using computed tomography (CT) with contrast may be utilized to assess the response.

Indexed as

brainhead and neckinterstitial photodynamic therapypancreaticprostatetreatment planning

Identifiers

PMID28125024
PMCPMC5332935
OpenAlexW2580285549

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.