Evidence map›Paper›PMID 28125015›Full record

ArticleInternational journal of molecular sciences2017

Polymorphisms of Dopamine Receptor Genes and Risk of L-Dopa-Induced Dyskinesia in Parkinson's Disease.

Cristoforo Comi, Marco Ferrari, Franca Marino, Luca Magistrelli, Roberto Cantello, Giulio Riboldazzi, Maria Laura Ester Bianchi, Giorgio Bono, Marco Cosentino

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.

  1. Polymorphisms of the dopamine metabolic and signaling pathways are associated with susceptibility to motor levodopa-induced complications (MLIC) in Parkinson's disease: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Pooled it
  2. Levodopa-induced dyskinesia in Parkinson's disease: still no proof? A meta-analysis.Journal of neural transmission (Vienna, Austria : 1996) · 2018
    Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Dopamine Pathway and Parkinson's Risk Variants Are Associated with Levodopa-Induced Dyskinesia.Movement disorders : official journal of the Movement Disorder Society · 2024
    Article
  8. Article
  9. Article
  10. FunctionalParkinson's disease · 2022
    Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Beta2-Adrenoceptor Agonists in Parkinson's Disease and Other Synucleinopathies.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020
    Review
  16. Article
  17. Article
  18. Revealing Adenosine AInternational journal of molecular sciences · 2019
    Article
  19. Article
  20. Levodopa-induced dyskinesia: clinical features, incidence, and risk factors.Journal of neural transmission (Vienna, Austria : 1996) · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Cristoforo ComiMovement Disorders Centre, Neurology Unit, Department of Translational Medicine, University of Piemonte Orientale, 28100 Novara, Italy. comi@med.uniupo.it.
Marco FerrariCenter of Research in Medical Pharmacology, University of Insubria, 21100 Varese, Italy. marco.ferrari@uninsubria.it.
Franca MarinoCenter of Research in Medical Pharmacology, University of Insubria, 21100 Varese, Italy. franca.marino@uninsubria.it.
Luca MagistrelliMovement Disorders Centre, Neurology Unit, Department of Translational Medicine, University of Piemonte Orientale, 28100 Novara, Italy. magis.luca@gmail.com.
Roberto CantelloMovement Disorders Centre, Neurology Unit, Department of Translational Medicine, University of Piemonte Orientale, 28100 Novara, Italy. cantello@med.uniupo.it.
Giulio RiboldazziDepartments of Biotechnology and Life Science, University of Insubria, 21100 Varese, Italy. g.riboldazzi@fastwebnet.it.
Maria Laura Ester BianchiDepartments of Biotechnology and Life Science, University of Insubria, 21100 Varese, Italy. mlebianchi@hotmail.com.
Giorgio BonoDepartments of Biotechnology and Life Science, University of Insubria, 21100 Varese, Italy. giorgio.bono@uninsubria.it.
Marco CosentinoCenter of Research in Medical Pharmacology, University of Insubria, 21100 Varese, Italy. marco.cosentino@uninsubria.it.
University of Insubria · ITUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro” · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

L-dopa-induced dyskinesia (LID) is a frequent motor complication of Parkinson's disease (PD), associated with a negative prognosis. Previous studies showed an association between dopamine receptor (DR) gene (

Indexed as

Polymorphism, GeneticAgedAllelesAnimalsDisease ProgressionDyskinesiasFemaleGenetic Predisposition to DiseaseGenotypeHumansKaplan-Meier EstimateLevodopaMaleMiddle AgedParkinson DiseasePolymorphism, Single NucleotideLevodopaReceptors, Dopaminedisease progressionmotor complicationsParkinson’s diseasepersonalized medicineSNPs

Identifiers

PMID28125015
PMCPMC5343779
OpenAlexW2581363708

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.