Evidence map›Paper›PMID 28124736›Full record

Trial reportIntensive care medicine2017

High flow nasal cannula (HFNC) versus nasal continuous positive airway pressure (nCPAP) for the initial respiratory management of acute viral bronchiolitis in young infants: a multicenter randomized controlled trial (TRAMONTANE study).

Christophe Milési, Sandrine Essouri, Robin Pouyau, Jean-Michel Liet, Mickael Afanetti, Aurélie Portefaix, Julien Baleine, Sabine Durand, Clémentine Combes, Aymeric Douillard and 2 more

3 registry-linked trialsAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Intensive care medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 103 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed, 17 pooled it
21.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03689686 naunknown statusnot on this mapstarted 2018, after this paper: background citation

Physiological Effects of High Flow Nasal Cannulas Oxygen Therapy vs Continuous Positive Airway Pressure in Pediatric Acute Respiratory Failure

TypeinterventionalSponsorFondazione IRCCS Ca' Granda, Ospedale Maggiore PoliclinicoRan2018 to 2018Enrolled15ConditionsAcute Respiratory FailureArmsNoninvasive Respiratory Support
NCT05784636 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Comparative Study on the Effectiveness, Comfort and Compliance of High-flow Nasal Oxygen Therapy and Noninvasive Mechanical Ventilation BiPAP Mode in the Treatment of Hypoxemia Patients

TypeinterventionalSponsorQilu Hospital of Shandong UniversityRan2023 to 2024Enrolled243ConditionsHypoxemiaArmsNon-invasive BiPAP ventilation, HFNC
NCT06249009 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Impact of Increasing Flow Rates in High-flow Nasal Cannula and CPAP on Diaphragmatic Work in Newborn and Paediatric Population: Non-inferiority Study

TypeinterventionalSponsorUniversity Hospital, Clermont-FerrandRan2023 to 2025Enrolled80ConditionsRespiratory Insufficiency in Children, Newborn Rds, Nasal Cannula, CPAP VentilationArmsNon invasive ventilation
3 · Its place in the literature

Who cites it

103 citing papers in PubMed, 17 syntheses or guidelines pooled it, 273 citations in OpenAlex.

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  2. Respiratory support in paediatric patients with bronchiolitis: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2026
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  8. High-flow nasal cannula therapy for infants with bronchiolitis.The Cochrane database of systematic reviews · 2024
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  9. High flow nasal cannula for respiratory support in term infants.The Cochrane database of systematic reviews · 2023
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43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Christophe MilésiPediatric Intensive Care Unit, Département de Pédiatrie Néonatale et Réanimations, CHU de Montpellier, Arnaud de Villeneuve University Hospital, 371 Avenue du Doyen G. Giraud, 34295, Montpellier Cedex 5, France.
Sandrine EssouriPediatric Intensive Care Unit, Kremlin Bicêtre University Hospital, Paris, France.
Robin PouyauPediatric Intensive Care Unit, Women-Mothers and Children's University Hospital, Lyon, France.
Jean-Michel LietPediatric Intensive Care Unit, Women and Children's University Hospital, Nantes, France.
Mickael AfanettiPediatric Intensive Care Unit, Lenval University Hospital, Nice, France.
Aurélie PortefaixPediatric Intensive Care Unit, Women-Mothers and Children's University Hospital, Lyon, France.
Julien BaleinePediatric Intensive Care Unit, Département de Pédiatrie Néonatale et Réanimations, CHU de Montpellier, Arnaud de Villeneuve University Hospital, 371 Avenue du Doyen G. Giraud, 34295, Montpellier Cedex 5, France.
Sabine DurandPediatric Intensive Care Unit, Département de Pédiatrie Néonatale et Réanimations, CHU de Montpellier, Arnaud de Villeneuve University Hospital, 371 Avenue du Doyen G. Giraud, 34295, Montpellier Cedex 5, France.
Clémentine CombesPediatric Intensive Care Unit, Département de Pédiatrie Néonatale et Réanimations, CHU de Montpellier, Arnaud de Villeneuve University Hospital, 371 Avenue du Doyen G. Giraud, 34295, Montpellier Cedex 5, France.
Aymeric DouillardDepartment of Medical Information, Arnaud de Villeneuve University Hospital, Montpellier, France.
Gilles CamboniePediatric Intensive Care Unit, Département de Pédiatrie Néonatale et Réanimations, CHU de Montpellier, Arnaud de Villeneuve University Hospital, 371 Avenue du Doyen G. Giraud, 34295, Montpellier Cedex 5, France. g-cambonie@chu-montpellier.fr.
Groupe Francophone de Réanimation et d’Urgences Pédiatriques (GFRUP)
Hôpital Arnaud de Villeneuve · FRBicêtre Hospital · FRCentre Hospitalier Universitaire de Nantes · FRFondation Lenval · FRHôpital Femme Mère Enfant · FRInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeNasal continuous positive airway pressure (nCPAP) is currently the gold standard for respiratory support for moderate to severe acute viral bronchiolitis (AVB). Although oxygen delivery via high flow nasal cannula (HFNC) is increasingly used, evidence of its efficacy and safety is lacking in infants.

methodsA randomized controlled trial was performed in five pediatric intensive care units (PICUs) to compare 7 cmH

resultsFrom November 2014 to March 2015, 142 infants were included and equally distributed into groups. The risk difference of -19% (95% CI -35 to -3%) did not allow the conclusion of HFNC noninferiority (p = 0.707). Superiority analysis suggested a relative risk of success 1.63 (95% CI 1.02-2.63) higher with nCPAP. The success rate with the alternative respiratory support, intubation rate, durations of noninvasive and invasive ventilation, skin lesions, and length of PICU stay were comparable between groups. No patient had air leak syndrome or died.

conclusionIn young infants with moderate to severe AVB, initial management with HFNC did not have a failure rate similar to that of nCPAP. This clinical trial was recorded in the National Library of Medicine registry (NCT 02457013).

Indexed as

Acute DiseaseBronchiolitis, ViralCannulaContinuous Positive Airway PressureHumansInfantInfant, NewbornInfant, PrematureIntensive Care Units, NeonatalOxygen Inhalation TherapyRespiratory Distress Syndrome, NewbornTreatment FailureBronchiolitisContinuous positive airway pressureHigh flow nasal cannulaInfantNoninvasive ventilationOxygen inhalation therapyRandomized controlled trialRespiratory syncytial virus infectionsRespiratory therapy

Identifiers

PMID28124736
OpenAlexW2580254438

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.