Evidence map›Paper›PMID 28124725›Full record

ReviewJournal of cancer research and clinical oncology2017

Phorbol esters in seed oil of Jatropha curcas L. (saboodam in Thai) and their association with cancer prevention: from the initial investigation to the present topics.

Hirota Fujiki, Maitree Suttajit, Anchalee Rawangkan, Keisuke Iida, Pornngarm Limtrakul, Sonthaya Umsumarng, Masami Suganuma

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of cancer research and clinical oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 23 citations in OpenAlex.

  1. Toxicology reports · 2025
    Review
  2. Article
  3. Functional characterization of theFrontiers in zoology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Hirota FujikiFaculty of Medicine, Saga University, Nabeshima, Saga, 849-8501, Japan. uv4h-fjk@asahi-net.or.jp.
Maitree SuttajitSchool of Medical Sciences, University of Phayao, Phayao, 56000, Thailand.
Anchalee RawangkanSchool of Medical Sciences, University of Phayao, Phayao, 56000, Thailand.
Keisuke IidaGraduate School of Science and Engineering, Saitama University, Sakura-ku, Saitama, 338-8570, Japan.
Pornngarm LimtrakulDepartment of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
Sonthaya UmsumarngGraduate School of Science and Engineering, Saitama University, Sakura-ku, Saitama, 338-8570, Japan.
Masami SuganumaGraduate School of Science and Engineering, Saitama University, Sakura-ku, Saitama, 338-8570, Japan.
Saitama University · JPChiang Mai University · THSaga University · JPUniversity of Phayao · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIn 1988, we first reported the complete chemical structure of a new type of phorbol ester, abbreviated to DHPB, found in seed oil of Jatropha curcas L. (Saboodam in Thai) and its tumor-promoting activity on mouse skin. Although this seed oil contains toxic phorbol ester, it was planned to use it as a feasible renewable oil and the extracted seed cake as fertilizer. This utilization value opened a new science of Jatropha curcas.

methodsThe main experimental results are cited from our publications, and the relevant literature screened from journals and PubMed. RESULTS AND DISCUSSION: This paper begins with our original work on the structural elucidation of a new phorbol ester, 12-deoxy-16-hydroxyphorbol (DHPB): its tumor-promoting activity was compared with that of TPA. We think that it is timely to review the following research advances with Jatropha curcas, so numerous topics are classified as follows: (1) historical development of phorbol esters in seed oil; (2) toxicity of phorbol ester based on various bioassays; (3) degradation of phorbol ester; (4) a new pharmaceutical compound in seed; and (5) tumor promotion and progression with endogeneous tumor promoters in human carcinogenesis. The discovery of phorbol ester in seed oil raised awareness of the danger of public use of seed oil and seed cake in Thailand, and also indicated the necessity of discussing the concept of primary and tertiary cancer preventions.

conclusionIt is worthwhile to study the future benefits and cancer risks of globally distributed Jatropha curcas L.

Indexed as

CarcinogenesisHumansJatrophaNeoplasmsPhorbol EstersPlant OilsSeedsPhorbol EstersPlant OilsDHPBEconomical fuelJatropha curcas L.Seed oilTumor promoter

Identifiers

PMID28124725
PMCPMC5504133
OpenAlexW2580572513

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.