Evidence map›Paper›PMID 28124714›Full record

ArticleSoft matter2017

Clathrin polymerization exhibits high mechano-geometric sensitivity.

Ehsan Irajizad, Nikhil Walani, Sarah L Veatch, Allen P Liu, Ashutosh Agrawal

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Soft matter, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ehsan IrajizadDepartment of Mechanical Engineering, University of Houston, Houston, TX, USA.
Nikhil WalaniDepartment of Mechanical Engineering, University of Houston, Houston, TX, USA.
Sarah L VeatchDepartment of Biophysics, University of Michigan, Ann Arbor, MI, USA.
Allen P LiuDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-0309-7018
Ashutosh AgrawalDepartment of Mechanical Engineering, University of Houston, Houston, TX, USA. ashutosh@uh.edu.ORCID http://orcid.org/0000-0002-9923-8603
University of Houston · USUniversity of Michigan · US

Funding

Ion channel regulation by heterogeneous membranesR01GM110052 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI VEATCH, SARAH L · 2014 to 2022
$2.9M
NIGMS NIH HHS R01 GM110052
6 · The paper itself

Abstract

How tension modulates cellular transport has become a topic of interest in the recent past. However, the effect of tension on clathrin assembly and vesicle growth remains less understood. Here, we use the classical Helfrich theory to predict the energetic cost that clathrin is required to pay to remodel the membrane at different stages of vesicle formation. Our study reveals that this energetic cost is highly sensitive to not only the tension in the membrane but also to the instantaneous geometry of the membrane during shape evolution. Our study predicts a sharp reduction in clathrin coat size in the intermediate tension regime (0.01-0.1 mN m

Identifiers

PMID28124714
PMCPMC5452080
OpenAlexW2575308662

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.